I was reading this article on methyl folate and thought it might be worth sharing with you all. Even in small doses, it made me feel awful. Anyway, just wondered what you thought about it. Do we need to take care with it, especially in higher doses?https://www.merrittwellness.com/mthfr-m ... out-mthfr/
"First, a little primer on the MTHFR enzyme (with the risk of me also oversimplifying!). Methylene tetrahydrofolate reductase is one of multiple enzymes which help your body pass around the “hot potato” of a methyl group. Methyl groups are found in many, many foods and are the source to add a carbon to molecules like DNA, hormones, phospholipids, neurotransmitters, proteins, etc. In the case of MTHFR, the methyl group helps to convert homocysteine to methionine. You might have heard homocysteine is correlated with cardiovascular disease, which is accurate, but you also need homocysteine to make glutathione, which is the body’s homemade antioxidant. So balance is key to remember here as well, since driving down homocysteine can also increase inflammation from insufficient glutathione.
Merck Pharmaceuticals designed 5-MTHF as an answer to the damage methotrexate does in its destruction of folate pathways in regards to treating cancer. In that particular case, taking 5-MTHF completely makes sense if you’re trying to rebuild those pathways. There can be isolated times where you might take it short term (like a week or two). But long term supplementation of methylfolate causes a list of side effects that rival a pharmaceutical drug: anxiety, irritability, insomnia (from changes in neurotransmitters), sore muscles and achy joints (from reduction in glutathione production), headaches and migraines (from increased nitric oxide production), nausea, palpitations, rashes and suicide, in addition to exacerbating B6 and B12 deficiencies, along with magnesium, zinc, copper, manganese and other mineral deficiencies."
- There is a lot more in there and it is worth reading the article in full.