The data on the Med. Diet is, to my eye, really good. The reCODE protocol - the original in the Aging papers - provides the "choice of anti-inflammatory diets", and mentions the Med. Diet specifically. So lately, I'm thinking that it might be better, for me at this point, to go that way. Or at least to try. I've mentioned it before - I do think there must be differences in what is best for those without symptoms at mid-life and those with symptoms later on..
Agree re. the Med Diet. In fact, KetoFlex 12/3 is sometimes described as a Mediterranean ketogenic lifestyle
. Lifestyle vs. diet as a long fast, exercise & diet are all combined to create a mild level of ketosis. It's worth noting that there are many similarities between traditional Med Diet and Dr. Bredesen's plan, the exceptions being pasta & pizza
In this case, if ketosis is supposed to provide an alternative fuel to insulin resistant brains I would guess that the benefits increase over time (and be less important earlier.)
Maybe, but we have a large body of work demonstrating a reduction in neuronal fuel per PET/FDG in our genotype (in a dose dependent fashion) as early as our 20s. The bioenergetics or mitochondrial hypothesis proposes that addressing that as early as possible
upstream of symptoms could avoid the downstream cascade of pathology. We know that the Alzheimer's disease process takes at least a decade, likely longer, to form. Younger people (such as yourself) may be able to simply incorporate a long daily fast and exercise to get into mild ketosis to address the reduction in cerebral glucose utilization. Older folks may need to work harder and include a stricter low carb diet. Lucky for us, we can easily test BHB to see where we stand.
JimBG, thanks for sharing your numbers and journey. We learn so much from case studies like yours. I'm barely functioning... still dealing with the flu
, so apologies if these are repeat questions. How old are you? Do you have a family or personal history of CAD? If you're age 45 or older, you may want to consider an EBT to check your calcium score to help guide your priorities. As you point out, advanced lipids would be another great test. You could also check your oxLDL to further hone in on your CAD risk. You've lost a lot of weight and body fat. How's your BMI? BP? I love the trend in your glucose numbers. I see a mixed bag with your results; lots of good stuff too. Keep up the great work and keep sharing. I suspect that you'll teach us all as you further work on tinkering your numbers.