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Prion Disease Antibody Helped Memory Substrate

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circular
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Prion Disease Antibody Helped Memory Substrate

Postby circular » Sun Jun 01, 2014 7:09 pm

I can't get the article 'cause it's behind a paywall, but my New England Journal Watch email noted it:

SUMMARY AND COMMENT
A New Approach to Alzheimer Disease
Steven Dubovsky, MD Reviewing Klyubin I et al., J Neurosci 2014 Apr 30; 34:6140

In a preclinical study, an antibody currently being studied for prion disease also shows positive findings for the biological substrate of memory.
ApoE 3/4 > Thanks in advance for any responses made to my posts.

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Re: Prion Disease Antibody Helped Memory Substrate

Postby Juliegee » Sun Jun 01, 2014 7:27 pm

Really interesting. Seems to go along with the "Mad Cow" connection. I'd like to learn more too if anyone has access.

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Re: Prion Disease Antibody Helped Memory Substrate

Postby circular » Sun Jun 01, 2014 7:42 pm

I've been seeing the prion theory pop up here and there but haven't really looked into it.
ApoE 3/4 > Thanks in advance for any responses made to my posts.

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Re: Prion Disease Antibody Helped Memory Substrate

Postby Juliegee » Sun Jun 01, 2014 8:18 pm

I think this was one of Rudy Tanzi's ideas and the basis of his recommendation for a vegetarian diet to prevent AD.

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Re: Prion Disease Antibody Helped Memory Substrate

Postby SusanJ » Mon Jun 02, 2014 7:28 am

Looks like the Dubovsky article is actually a review of this research published in April. Full text at the link.

Peripheral Administration of a Humanized Anti-PrP Antibody Blocks Alzheimer's Disease Aβ Synaptotoxicity
http://www.jneurosci.org/content/34/18/6140.full

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Re: Prion Disease Antibody Helped Memory Substrate

Postby Juliegee » Mon Jun 02, 2014 7:52 pm

Thanks, Susan. Boy, I've been going down the proverbial rabbit hole with this one :roll: The prion theory has been around a long time. The idea that AD is transmittable is intriguing. Rudy Tanzi think's it's transmitted by eating meat. Given the profit-driven commercial feedlot system of meat production in the US...he may be on to something. Here's a nice overview of how the prion hypothesis has panned out from the 70s-present.

http://dana.org/News/Details.aspx?id=43210

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Re: Prion Disease Antibody Helped Memory Substrate

Postby SusanJ » Sun May 17, 2015 10:54 am

Back to prions...just when we thought it was all about the meat.

Grass plants can bind, uptake and transport infectious prions, according to researchers.


http://www.sciencedaily.com/releases/20 ... 155636.htm

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Re: Prion Disease Antibody Helped Memory Substrate

Postby ApropoE4 » Wed May 20, 2015 12:55 pm

Juliegee wrote:Thanks, Susan. Boy, I've been going down the proverbial rabbit hole with this one :roll: The prion theory has been around a long time. The idea that AD is transmittable is intriguing. Rudy Tanzi think's it's transmitted by eating meat. Given the profit-driven commercial feedlot system of meat production in the US...he may be on to something. Here's a nice overview of how the prion hypothesis has panned out from the 70s-present.

http://dana.org/News/Details.aspx?id=43210


I thought there are experiments showing the only way to "transmit" AD was to implant Ab oglimer infested tissue directly into the target brain, which makes it not very transmittable at all. (and of course we know it's not transmittable because, you know, there are no epidemiological patterns supporting an even weakly transmittable nature)

Re. PrP antibodies - as far as I can remember, they need to be fed directly into the brain, which in turn tends to develop antibodies to try and fight them off, finally resulting in severe inflammation. Unlikely to be helpful, although they may prove a useful research tool.


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