circular wrote:My DHEA lab came back 141 mcg/dL. The Labcorp range is 26-200. My doctor understandably feels it's fine. Dr. Bredesen's 'target' is 350-430 mcg/dL in women and 400-500 mcg/dL in men. This is so much higher than the lab range I'd really like to see some papers justifying it, even if it's a neurosteroid like pregnenolone. His target for pregnenolone is much more in line with lab ranges.
Great question. I don't know the answer but can share what my functional medicine/hormone replacement/Bredesen trained MD told me about my DHEA level. Now that I'm reviewing my labs for the last 1.5 years (sheesh! time flies), I notice an inconsistency. My misunderstanding? Don't know. Here goes...
My initial DHEA reading without any hormone/supplement use was 39 ug/dL. My notes from that lab review with FM MD indicate >500 as target.
My levels on DHEA 5mg supplementation have been in the 120's, and she said that was "ideal." Flip a coin?
That being said, my estrone levels have been high since starting rx bHRT with DHEA and pregnenolone 10 mg supplements. Estrone is considered a marker for a metabolite of estradiol that increases risk for breast cancer. Three attempts at lowering the estrone levels - adding 2 different supplements in stepwise fashion (Estrosense and Calcium D Glucarate), and lowering the estradiol dose - helped lower the estrone but not enough. Fourth step - stopping DHEA. And voila! Normal estrone level. This most recent result has not yet been reviewed with said MD, and won't be for another month. I plan to ask about slowly reducing the Estrosense and Calcium D Glucarate to lighten my stack load.
Somewhat tangential N=1 story, but definitely related to DHEA. Tread cautiously.