Dr Bredesen's DHEA Target High???

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circular
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Dr Bredesen's DHEA Target High???

Postby circular » Fri Jun 15, 2018 11:41 am

My DHEA lab came back 141 mcg/dL. The Labcorp range is 26-200. My doctor understandably feels it's fine. Dr. Bredesen's 'target' is 350-430 mcg/dL in women and 400-500 mcg/dL in men. This is so much higher than the lab range I'd really like to see some papers justifying it, even if it's a neurosteroid like pregnenolone. His target for pregnenolone is much more in line with lab ranges.

Any thoughts?
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Re: Dr Bredesen's DHEA Target High???

Postby slacker » Sat Jun 16, 2018 5:15 am

circular wrote:My DHEA lab came back 141 mcg/dL. The Labcorp range is 26-200. My doctor understandably feels it's fine. Dr. Bredesen's 'target' is 350-430 mcg/dL in women and 400-500 mcg/dL in men. This is so much higher than the lab range I'd really like to see some papers justifying it, even if it's a neurosteroid like pregnenolone. His target for pregnenolone is much more in line with lab ranges.

Any thoughts?


Great question. I don't know the answer but can share what my functional medicine/hormone replacement/Bredesen trained MD told me about my DHEA level. Now that I'm reviewing my labs for the last 1.5 years (sheesh! time flies), I notice an inconsistency. My misunderstanding? Don't know. Here goes...

My initial DHEA reading without any hormone/supplement use was 39 ug/dL. My notes from that lab review with FM MD indicate >500 as target.
My levels on DHEA 5mg supplementation have been in the 120's, and she said that was "ideal." Flip a coin?

That being said, my estrone levels have been high since starting rx bHRT with DHEA and pregnenolone 10 mg supplements. Estrone is considered a marker for a metabolite of estradiol that increases risk for breast cancer. Three attempts at lowering the estrone levels - adding 2 different supplements in stepwise fashion (Estrosense and Calcium D Glucarate), and lowering the estradiol dose - helped lower the estrone but not enough. Fourth step - stopping DHEA. And voila! Normal estrone level. This most recent result has not yet been reviewed with said MD, and won't be for another month. I plan to ask about slowly reducing the Estrosense and Calcium D Glucarate to lighten my stack load.

Somewhat tangential N=1 story, but definitely related to DHEA. Tread cautiously.
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Re: Dr Bredesen's DHEA Target High???

Postby TheBrain » Sat Jun 16, 2018 5:47 am

All I can say is that I’d probably develop facial hair if my DHEA were that high.
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Re: Dr Bredesen's DHEA Target High???

Postby Surupe » Thu Feb 07, 2019 8:55 pm

Did you ever get resolution on this issue, circular? I am having the same issue with DhEA. Mine is 452 which is a bit high. I did take DHEA supplements (25mg) because I was low before. I also started esting a lot of meat in this time frame thanks to Keto. However, my doc wants the levels around 200 and he’s concerned.
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Re: Dr Bredesen's DHEA Target High???

Postby circular » Sat Feb 09, 2019 1:11 pm

Surupe wrote:Did you ever get resolution on this issue, circular? I am having the same issue with DhEA. Mine is 452 which is a bit high. I did take DHEA supplements (25mg) because I was low before. I also started esting a lot of meat in this time frame thanks to Keto. However, my doc wants the levels around 200 and he’s concerned.

Hi, I never supplemented. I can't justify following Dr. Bredesen's advice with something to go on. But something tells me maybe this has to do with a difference between DHEA and DHEA-S??? Dr. Bredesen's recommendation is for DHEA-S. I can never find time to enter all my old labs into my lab results app, so I'm not sure if I tested DHEA or DHEA-S.
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Re: Dr Bredesen's DHEA Target High???

Postby harpsicon » Mon Feb 11, 2019 1:11 pm

I think they're the same. Dr. Bredesen talks about dehydroepiandrosterone (DHEA), but in his goals, he talks about DHEA Sulfate, and gives the numbers quoted here. Probably that's the "S"... but you're certainly right, his goals are more different here than in most categories, although a theme of his book is how "normal" readings may be very "Not OK".

Bredesen, Dale. The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline (p. 131). Penguin Publishing Group. Kindle Edition.


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