Deep sleep and the ADA gene were discussed in April by Alexis and NF52 viewtopic.php?f=33&t=4654&hilit=ADA
Although the minor (5%) T (A) allele of the ADA gene is associated with more deep sleep, it has both positive and negative aspects and might be worth checking out when setting sleep goals.
Fitbit at http://www.sleepreviewmag.com/2017/06/s ... ep-stages/
reported deep sleep percentage varies with age, gender, and sleep duration.
When getting 5 hours or less of sleep a night, users get a smaller percentage of deep sleep, which occurs near the beginning of the night. Deep sleep is important for many physical processes such as cell regeneration, human growth hormone secretion and feeling refreshed in the morning.
Gen Z (age 13-22) sleeps the most, averaging 6 hours and 57 minutes of sleep a night with 17% of the time in deep sleep, while Baby Boomers (age 52-71) sleep the least at 6 hours and 33 minutes per night with 13% of the time in deep sleep.
People get less deep sleep as they age, decreasing from an average of 17% at age 20 to 12% at age 70.
Women sleep an average of 25 more minutes a night than men and have a higher percentage of REM sleep, a difference which increases even further around age 50.
Previous sleep research has shown that most people spend 50-60% of their night in light sleep, 10-15% in deep sleep, and 20-25% in REM sleep. Fitbit analysis shows that age and gender impact your sleep cycle, and confirm that most people typically lie within these ranges on average over 30 days. Night-to-night sleep cycles may vary widely.
23andMe reports deep sleep regulation is controlled by your rs73598374 allele in the ADA gene (which produces the enzyme adenosine deaminase, which converts adenosine to inosine.) The longer you stay awake the more adenosine builds up, so metabolizing it promotes deep sleep.
selfdecode.com reports the T (minor, 5%) allele of rs73498374 causes less amino acid substitution and is associated with positive and negative effects https://www.selfdecode.com/snp/rs73598374/
Adenosine increases minimum lifespan but reduces maximum lifespan. It's believed that elevated cellular concentrations of adenosine reduce heart disease risk and can help during a stroke
More adenosine translates into increased slow-wave sleep in individuals with the T allele https://www.ncbi.nlm.nih.gov/pubmed/217 ... t=Abstract http://www.zora.uzh.ch/id/eprint/48649/
T (A) carriers had less cognitive performance than G (C) when awake in spite of more deep sleep. Naps might help more than nighttime sleep.
Worsened performance on a test of attention among right-handed carriers (R).
Reduced attention and vigor when awake. Also, EEG alpha activity (8.5-12 Hz), sleepiness, fatigue, and α-amylase in saliva were enhanced (R).
Significantly higher deep sleep and EEG 0.75- to 1.5-Hz oscillations in non-REM sleep. When awake, attention and vigor were reduced. EEG alpha activity (8.5-12 Hz), sleepiness, fatigue, and Œ-amylase in saliva were enhanced (R).
Better sleep, but more fatigue in the day due to higher adenosine levels.
Lower telomerase activity (R), which will cause shorter telomeres.
A higher likelihood for males to live between 66-88 years, but a lower likelihood for men to live longer than 88 years (R). It’s believed that elevated cellular concentrations of adenosine reduce heart disease risk, as well as help during a stroke (R).
Higher rates of glycolysis, which may increase the number of metabolic calories and, in turn, reduce activation of Sirtuin genes (R).