What is considered atrophy in a brain structure per MRI volumetrics (NeuroQuant and Neuroreader)?

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TheBrain
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Re: What is considered atrophy in a brain structure per MRI volumetrics (NeuroQuant and Neuroreader)?

Postby TheBrain » Fri Feb 28, 2020 9:00 am

Indywoman wrote:Oh dear. I am so sorry. One never knows all the caveats and disclaimers to ask about up front, and hindsight often won't correct those issues without more money and certainly more time. My MRI scan location was slow getting the scans and reports to the neurologist, and did not tell me until I asked about the other reports, that they were free. When I called, I said, "This is like trying to get the results from the Iowa Caucus!"

This must be especially hard on you because you had to travel 5 hours round trip, and future scans have to be done at the same place/scanner according to CorTechs, in order to get accurate tracking. The reports however, are very useful and informative.


Thanks, Indywoman. I wouldn't mind paying for the reports if they were actually available. I'll try to encourage the clinic to upgrade to the latest NeuroQuant version, but I'd be shocked if I have any influence on them.

Fortunately, NeuroQuant is now available at more radiology clinics and hospitals. Unfortunately, none of them are closer to me than that clinic. Maybe the universe is telling me not to retest right now.
ApoE 4/4 - When I was in 7th grade, my fellow students in history class called me "The Brain" because I had such a memory for detail. I excelled at memorization and aced tests. This childhood memory helps me cope!

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Re: What is considered atrophy in a brain structure per MRI volumetrics (NeuroQuant and Neuroreader)?

Postby TheBrain » Fri Feb 28, 2020 9:07 am

When someone goes for their latest MRI with NeuroQuant and has one or more previous scans with NeuroQuant data with which to compare results, I wonder if radiology clinics could re-run all previous NeuroQuant reports already generated as well as the latest reports using the current normative database. If so, they could compare apples to apples.
ApoE 4/4 - When I was in 7th grade, my fellow students in history class called me "The Brain" because I had such a memory for detail. I excelled at memorization and aced tests. This childhood memory helps me cope!

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Re: What is considered atrophy in a brain structure per MRI volumetrics (NeuroQuant and Neuroreader)?

Postby circular » Fri Feb 28, 2020 9:34 am

Indywoman wrote:
Circular wrote:
In fact, if in the fairly distant future you run a new MRI to compare it with your NeuroQuant baseline, then if CorTechs is using much, much larger reference populations coming out of big data studies, then the comparison won't be apples to apples. So will NeuroQuant just continue to use what will be an outdated dataset so people can make comparisons over time, despite what will become outdated percentiles? Does their dataset already change from version 1 to version 2 to version 3, or are the changes only more display oriented using the same data?


This is an interesting conundrum, not just for NeuroQuant and CorTech Labs but in any normative database for a medical condition. It would seem that the larger the database, let's say for Alzheimer's, the more epigenetic factors would come into play, especially if it were a global database. We have at least reached the point where databases are giving norms based on age, sex, and now starting on race. That's progress!

Would I want to be normed in a database that includes Denmark or Norway where a number of governmental decisions have made them more economically secure and happier (overall less stressed) than in the U.S.? Or with Finns added in who come out near the top of the "happiness index", but also have one of the highest dementia mortality rates? Would a large database in one's own country be preferable to a larger one including other countries or vice versa?

You raise such interesting questions, Circular. Yes, indeed, this does pose issues for tracking over time from an initial baseline, if the normative databases used in that baseline become outdated as more studies take place.

I think it's possible that a patient's results will eventually be compared to multiple databases. The good news to your geography/genetics/environment point is that so many countries are starting up their own large whole genome projects. So perhaps CorTechs will compare to research out of the All of Us, UK Biobank and other large datasets and even more specifically by certain phenotypes and epigenetic factors wtihin them.
ApoE 3/4 > Thanks in advance for any responses made to my posts.

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Re: What is considered atrophy in a brain structure per MRI volumetrics (NeuroQuant and Neuroreader)?

Postby tb4423 » Tue Sep 21, 2021 1:30 pm

Hello
Im new to this board & am glad its here to ask question. Not sure where to post a question about Neuroquant results? My question is related to the validity of the results. Is every lab authorized to give the test trained to read the results ?
Thank you

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Re: What is considered atrophy in a brain structure per MRI volumetrics (NeuroQuant and Neuroreader)?

Postby ro.oconnor » Tue Sep 21, 2021 6:50 pm

tb4423 wrote:Hello
Im new to this board & am glad its here to ask question. Not sure where to post a question about Neuroquant results? My question is related to the validity of the results. Is every lab authorized to give the test trained to read the results ?
Thank you


A warm welcome to the ApoE4.Info website, tb4423! I'm so glad that you found us!

I see that you are inquiring whether labs that offer Neuroquant have people who are qualified to read them. I think your best bet here would be to call the specific location(s) that you are thinking of using. Neuroquant requires a referral from the patient's neurologists, some of whom may not be familiar with the specific protocol used by Neuroquant. It may also be beneficial to check with your insurance provider beforehand to find out if there will be full or partial coverage with your plan.

I hope this information is helpful to you! You may receive other responses to your post from other members with additional information or experience in this area.

Here are some tips and links that might be useful as you explore the website:

As you may have already discovered, there is a helpful search tool available in the top right-hand side of the webpage that you can access by selecting the three dots next to your log-in id. There you can search for topics in the various forums.

You may also find the Primer helpful, as it includes researched-based prevention strategies.

Additionally, you may want to check out the How-to Guide which includes tricks and tips for getting the most out of the discussion forums.

And finally, you may be interested in visiting Our Stories. There you can browse the stories of other members and if you are comfortable, share your own.

I hope you will continue to find the site helpful on your health journey. If there is anything else you want to know and can't find it on the site, please don't hesitate to reach out!

Warmly,
Rosanne
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Re: What is considered atrophy in a brain structure per MRI volumetrics (NeuroQuant and Neuroreader)?

Postby tb4423 » Tue Sep 21, 2021 7:42 pm

Thank you for your response .Ive had the Neuroquant already & was listening to one of the Neuroquant videos on You Tube where they said some radiologists will consider some things normal or age related when in fact they might be a warning sign?
But I would assume the radiologist reading it should be trained in what theyre looking for ?

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Re: What is considered atrophy in a brain structure per MRI volumetrics (NeuroQuant and Neuroreader)?

Postby TheBrain » Wed Sep 22, 2021 4:30 am

tb4423 wrote:Thank you for your response .Ive had the Neuroquant already & was listening to one of the Neuroquant videos on You Tube where they said some radiologists will consider some things normal or age related when in fact they might be a warning sign?
But I would assume the radiologist reading it should be trained in what theyre looking for ?


I had two radiologists review my NeuroQuant reports. They didn’t know how to interpret the reports, so all they did was look at the MRI images. And they were wrong on just about everything.

I had a consultation with Mary Ackerley, MD, who I presume is still in Arizona. She has reviewed many of these reports. I was satisfied with her interpretation and recommendations, although she was reluctant to tell me that I have cerebral white matter atrophy. I want the truth, the whole truth, and nothing but the truth.

Could you please provide a link to the video you watched? I’d like to watch it myself.
ApoE 4/4 - When I was in 7th grade, my fellow students in history class called me "The Brain" because I had such a memory for detail. I excelled at memorization and aced tests. This childhood memory helps me cope!

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Re: What is considered atrophy in a brain structure per MRI volumetrics (NeuroQuant and Neuroreader)?

Postby tb4423 » Wed Sep 22, 2021 8:27 am

There are several on You Tube if you search Neuroquant. Many are trainings & others are case studies. I believe the one with Dr.Brewer is the one they discussed misdiagnosis.

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Re: What is considered atrophy in a brain structure per MRI volumetrics (NeuroQuant and Neuroreader)?

Postby TheBrain » Wed Sep 22, 2021 10:09 am

tb4423 wrote:There are several on You Tube if you search Neuroquant. Many are trainings & others are case studies. I believe the one with Dr.Brewer is the one they discussed misdiagnosis.


Thanks! I'll try to find the Dr. Brewer video first. I'm overdue for my 2nd MRI w/ NeuroQuant, but thanks to our present circumstances, I'm holding off.

There's a clinic near me that offers the ReCODE protocol. I spoke once with one of the practitioners, and he can order another NeuroQuant for me. But in his opinion, what matters most is how the brain is functioning. As part of his initial assessment, he does what's called "functional brain mapping." So when the time comes, I'll work with him and do that as well.
ApoE 4/4 - When I was in 7th grade, my fellow students in history class called me "The Brain" because I had such a memory for detail. I excelled at memorization and aced tests. This childhood memory helps me cope!


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