Juliegee wrote:I keep getting hung up on some of his more outrageous claims, i.e. that LDL-P doesn't matter. He may be 100% correct; per his clinical work, he is. But I wish he'd publish his protocol for E4s in a respected peer reviewed journal for scrutiny from his peers. That being said, I think you're very wise to follow his protocol AND keep your LDL-P low.
Can you help me understand the difference between sdLDL and small LDL-P? He puts a lot of stake on sdLDL. I want to understand exactly what that is. Also, with regards to E4 carriers, he puts a lot of credence into oxLDL, but he doesn't test it? FWIW, mine tested in the lowest quartile and I basically loosely follow his approach. I really want to test adiponectin now. I suspect I'm one of those thin women who may be very sensitive. If so, what in the world will I eat? No peppers, tomatoes, cucumbers, etc. What is in your salads?
As to salads, here is what can be in a typical dinner, 4 oz guacamole (Wholly Guacamole) kimchee, sauerkraut, coconut kevita, nuts macadamia, brazil and/or hazelnuts, thawed shrimp (or lobster, clams & etc), steamed asparagus, salad (various combinations of): spinach, kale, arugula, chard, green onions, mushrooms, cilantro, ½ avocado, radish, carrots, mint, parsley, cabbage, cauiliflower, broccoli, brussels sprouts, black olives, palm hearts, artichoke hearts, jicama, dandelion greens. Unfiltered EVOO, balsamic vinegar. Sometimes make cabbage steaks, baked plantain chips. Sometimes a glass of red wine. Sometimes make bone broth. Usually chill the broth and scoop off the fat.
As to
sdLDL and small LDL-P, no I can't tell you the difference. I pulled an NMR two days after the
Singulex for
Gundry. LDL-P was 1292 and small LDL-P was <90 (off scale low). On the HDL labs had an LDL-P of 1377 and small LDL-P of 435 (in the green in HDL's eyes) with
sdLDL of 28.
sdLDL was 24 on the
Singulex. On the other hand my
wife's HDL labs had an LDL-P of 2380 and small LDL-P of 1382 with
sdLDL of 34. She was 31
sdLDL on the
Singulex. He's concerned about her
sdLDL and not in the least with her LDL-P. From my post: "Says there is an East Coast faction (uses LDL-P to scare everyone onto a statin) on cholesterol and a West Coast faction (trained by Berkely Heart Labs). West Coast guys think using high dose statins to drive LDL-P<1000 is crazy. " He mentioned he's in lipid discussion groups where they "yell at each other." He obviously knows he's not in the mainstream.
I'm probably not going to worry about LDL-P - for example, knowing that coconut/MCT oil will spike it. Going on his advice, I'll use them.
As to publishing. I think we are lucky he's published what he has. As a guy in clinical practice with nobody supporting the publishing, I'm amazed he does what he does.
For us, we are happy to pursue his path, given his clinical results. From reading comments on the two FB groups that follow his approaches, my
wife and I are at the healthy end of the spectrum. Many comment what huge positive changes he's made in their health. One lady (a month or two ago) said the first time she met him was in the hospital when he was doing a pre-op for a quintuple bypass (that he would perform). Instead of doing the surgery, he got her to adopt his program. She did that instead of the bypass and was posting to tell everyone how great she felt. If, when we retest our EBT scans, they've increased dramatically (which I'd be willing to bet they won't), we'll reevaluate. I've known I've had an elevated PLAC or LpPla2 score. He's the only person who has suggested he can get it lowered.
Heck Juile, nobody I'm aware of tests for E4 status. He's said he's treated 10,000 patients in 15 years (not that other clinicians don't see those numbers, but the routine testing he does is much more detailed than I've seen). He is addressing heart, cognition and autoimmune issues. I'm impressed. The other thing is he is not dogmatic. He laid out his metrics -
sdLDL, inflammatory markers (like TNF-alpha), IGF-1 and said "see what you can get away with while keeping these metrics low." It isn't like he says you can't eat X. It is more like, will your body let you get away with eating X and not spiking the markers.