Robhypno wrote:Just completely confused
Keto
Bredesen keto flex
Grundy plant
Which diet is recommended for E4?
Interesting you find the two conflicting. I’ve been following Dr Bredesen for years and have been a patient of Dr Gundry for years and find the divergences to be minor. Dr Gundry’s
Plant Paradox book came out in April 2017, I read it right away, Dr Bredesen’s
The End of Alzheimer’s book came out a few months later in August 2017 and read it right away too, although having followed him, I’d heard of much of what he’d addressed in the book.
Having read both books nearly back to back, I found much overlap between with them being quite complementary despite the fact one is a general health diet book and the other is a book specifically addressing Alzheimer's.
Dr Gundry emphasizes diet specifically, since that’s what he does as a practicing physician. He’s a heart surgeon turned functional doctor, which he calls restorative medicine. Around 18 years ago or so, he realized he no longer wanted to cut on diseased individuals when he knew he could help them heal themselves through diet and supplements.
Dr Bredesen addresses the pathologies of Alzheimer’s disease and strategies to address them, but having been a researcher in the lab all his life, his dietary recommendations are more generalized.
Dr Bredesen tends to recommend strictly from a cognition/neurodegenerative perspective.
Dr Gundry tends to recommend from an overall health/longevity perspective, in fact his next book coming out in March addresses longevity specifically.
Both recommend ketosis for cognition issues.
Both recommend meat as a condiment.
Both emphasize maintaining a low HbA1c, blood sugar and insulin levels.
Both offer strategies to keep inflammation low.
Both emphasize a low homocysteine level.
Where they have diverged in the past, I’ve noticed recent convergence:
- -Dr Bredesen recommended staying away from gluten, whereas Dr Gundry went beyond that recommending reducing lectin consumption, in a recent podcast Dr Bredesen discussed reducing lectins.
-Dr Bredesen recommends MCT oil largely because it can produce a brain/cognitive boost through ketones. Dr Gundry is a little more hesitant, especially for ApoE4s because of the saturated fat content, only recommending it if cognition is an issue.
-Dr Gundry recommended niacinamide for us, Dr Bredesen has mentioned nicotinamide riboside. Nicotinamide robiside is expensive. In his consultations Dr Gundry tries to be mindful of the cost of the supplements he recommends, he’s said all things being equal he also prefers nicotinamide robiside, but niacinamide is cheaper. They do diverge on homocysteine level a bit. Dr Gundry has observed niacinamide tends to raise homocysteine a bit, so he’s a little more relaxed than Dr Bredesen.
-I’m sure there’s more.
Which diet is recommended for E4?
There is no diet that everyone can agree upon is the best for an ApoE4 carrier.
Dr Bredesen makes his recommendations for all genotypes although he is extremely familiar with the ApoE4 allele and its unique issues and discusses it in his book.
Dr Gundry is also very familiar with the ApoE4 allele. Shortly after he began his restorative medicine practice, he started testing for it along with many other biomarkers and over the years he’s observed unique qualities/responses that his ApoE4 patients had. He addresses ApoE4 in his Plant Paradox book, although only lightly. Dr Gundry has a video where he presents his dietary recommendations for ApoE4s and a summation of those recommendations and a link to Dr Gundry's video can be found in the Wiki, Dr Gundry's Protocol
https://wiki.apoe4.info/wiki/Dr_Gundry%27s_Protocol
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