IL-6 in Inflammation, Immunity, and Disease
http://cshperspectives.cshlp.org/conten ... 16295.full
Specific to CVD:
Association between Serum Interleukin-6 Concentration and Mortality in Patients with Coronary Artery Disease
Th17 cells produce IL-17a, which amplifies inflammation by producing TNF-a cytokines among others.
Interleukin-17 and acute coronary syndrome
But here's an interesting one I just read:
Atherosclerosis is a chronic inflammatory arterial disease driven by both innate and adaptive immune responses to modified lipoproteins and components of the injured vascular wall. Specific T lymphocyte responses driven by T helper-1 or T regulatory cells play distinct and opposing roles in atherosclerosis. More recently, T helper-17 cells, which produce the prototype cytokine interleukin-17, have been characterized and shown to be critical in mucosal host defense against microbial and fungal pathogens. Sustained production of interleukin-17 in an inflammatory context has been linked to the pathology of several autoimmune and inflammatory diseases. However, regulatory and protective roles have also been reported in selective disease settings. Studies in atherosclerosis led to conflicting results on the roles of interleukin-17 and T helper-17 cells in disease development and plaque stability. The present review provides a summary of the available evidence and putative mechanisms linking this pathway to atherosclerosis, as well as a perspective on the risks and benefits of interleukin-17–targeted cytokine therapy in patients at high cardiovascular risk.
http://atvb.ahajournals.org/content/ear ... 114.303567
Hmm, maybe related to CIRS???