Once insulin resistance is healed and metabolic flexibility is restored (or if it's never been lost) a long daily fast, exercise, avoidance of sugar and refined carbs may be enough.
bikerman wrote:OK, since posting I read up on ketogenesis in the wiki here: https://www.apoe4.info/wiki/Ketosis_and_Ketogenic_Diet. So my question is: Without cognitive issues (and 4/4), should I go on a full keto diet as a pre-emptive measure, or alternatively just practice good healthy lifestyle habits of LCHF (Low Carb High Fat) clean diet, daily exercise, and daily fast. In other words, are there clear benefits of going into ketosis and having my liver create ketones for fuel?
Prolonged exposure of BBB endothelial cells to KBs induce expression of monocarboxylate transporters and enhances brain uptake rate of KBs. In addition, cell migration and expression of gap junction proteins are upregulated by KBs. Altogether, these reports suggest that the beneficial effects of the ketogenic diet may depend on increased brain uptake of KBs to match metabolic demand and repair of a disrupted blood-brain barrier (BBB). As the effects of KBs on the BBB and its transport mechanisms across the BBB are better understood, it will be possible to develop alternative strategies to optimize its therapeutic benefits for brain disorders where the BBB is compromised.
bikerman wrote:If asymptomatic, is the keto diet really necessary? Are there any known risks of the keto diet, such as gut health or missing out on certain types of nutrients? Are there any drawbacks to not including whole grains in our diets?
whole grains are particularly insidious,
striking dose-response evidence indicates that the relationships to several non-communicable diseases could be causal. Implementation of recommendations to increase dietary fibre intake and to replace refined grains with whole grains is expected to benefit human health.
TheresaB wrote:In 2017, I attended Low Carb USA in San Diego and one of the presentations was provided by Dr Georgia Ede entitled, "Preventing Alzheimer's is Easier than you think. How Sugar affects the brain" Unfortunately it is not available on the web without paying for it, but in the presentation she posited a sort of dietary spectrum depending how healthy a person is with regard to insulin resistance, it made a lot of sense to me. As one progresses down this ladder, she proposed that the diet get stricter. Do recognize that a person is asymptomatic through most of these steps. She also said that by the time symptoms start to become noticeable, our precious hippocampus in the brain (responsible for memory) has atrophied 10%. The progression of Alzheimer's takes decades.
Healthy – Clean, Whole, Real Foods Diet
Mildly Insulin Resistant – Low Carb, High (good) Fat diet
Moderately Insulin Resistant – Low Carb, High (good) Fat diet, a little stricter
Mild Cognitive Impairment – Ketogenic diet
Alzheimer’s Disease – Strict Ketogenic diet
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