Progesterone

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GemmaJ
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Progesterone

Postby GemmaJ » Sun Apr 28, 2019 2:13 am

Hello Everyone,

I'm wondering if anyone can offer me some advice. I have just started on BHRT. My hormones are chronically low for someone my age - my fault totally after years of abusing my body through anorexia. I'm APOE 4/4 and have followed a ketogenic diet with a 13/14 hour fast for the last 3.5 years since I discovered my genetic status and my Mum died from Alzheimers at 70 years of age.

My problem is that my BHRT doctor has told me to take progesterone 2-3 hours after evening meal, just before going to bed with fatty food. The actual advice was to take it with a big bowl of full fat yoghurt as apparently the progesterone needs to "sit in fat" to be able to to be properly absorbed. This obviously causes me a few problems - I don't eat dairy for a start and this interrupts my fasting period. Last night I used MCT oil - I was told that if I insisted on doing this I should take 4 "spoonfuls" (I used 2 teaspoonfuls!) but I feel very uncomfortable breaking my fast like this.

Has anyone else heard of these absorption issues or had the same problem?

Any advice would be very welcome.

Thank you everyone!

circular
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Re: Progesterone

Postby circular » Sun Apr 28, 2019 9:22 am

I take my progesterone pill before bed without food and my levels now are in range, so I question your docs advise. Maybe you could try without the food and see where your measurements comes out? I hope others respond who may know more about this.
ApoE 3/4 > Thanks in advance for any responses made to my posts.

GemmaJ
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Re: Progesterone

Postby GemmaJ » Sun Apr 28, 2019 9:33 am

Thanks circular. That's what I'm thinking too....It's good to hear someone speak your thoughts though. Thank you!

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Stavia
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Re: Progesterone

Postby Stavia » Sun Apr 28, 2019 1:52 pm

Hi Gemma
If your absorption of the progesterone is compromised by taking it fasting, here are two options
1. Take it with your dinner. Honestly, there is no science why it needs to be taken ar bedtime. It can be sedating, but if you are at home just chilling, its not a problem.
2. Take it at bedtime fasting, and check blood levels. If they are suboptimal, just increase the dose. Your doc has just made up the 4 spoons rule. There is no evidence here either that I know of.

Good luck.


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GemmaJ
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Re: Progesterone

Postby GemmaJ » Sun Apr 28, 2019 2:05 pm

Thanks Stavia.

It all sounded bit odd to me and I couldn't find anything about it on the internet. I just needed to hear some other voices of reason. All sensible advice - thank you! Gx

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slacker
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Re: Progesterone

Postby slacker » Sun Apr 28, 2019 4:57 pm

I take my progesterone 200 mg at bedtime with water, approx 3 hours after eating. My levels tend to run low-ish but this dose of progesterone seems to be the maximum recommended. I had been taking the dose at my evening meal without problems for quite a while, but eventually started to feel off balance and incredibly fatigued about 2 hours later. Once I change to taking the progesterone at bedtime, the fatigue and off balance sensation resolved. My blood levels are similar taking with food and at bedtime. N=1!
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Re: Progesterone

Postby maddanwill » Tue May 07, 2019 7:11 am

slacker wrote:I take my progesterone 200 mg at bedtime with water, approx 3 hours after eating. My levels tend to run low-ish but this dose of progesterone seems to be the maximum recommended.


Slacker, I am taking 400 mg of progesterone as prescribed by my doc. She said my progesterone/estrogen ratio was off. I do carry a gene that predisposes me to estrogen dominance. I read your post and was wondering who recommends 200 mg as being the max recommended dose? BTW the increase to 400 has helped my sleep. Thanks!

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Re: Progesterone

Postby slacker » Tue May 07, 2019 8:53 am

maddanwill wrote:
slacker wrote:I take my progesterone 200 mg at bedtime with water, approx 3 hours after eating. My levels tend to run low-ish but this dose of progesterone seems to be the maximum recommended.


Slacker, I am taking 400 mg of progesterone as prescribed by my doc. She said my progesterone/estrogen ratio was off. I do carry a gene that predisposes me to estrogen dominance. I read your post and was wondering who recommends 200 mg as being the max recommended dose? BTW the increase to 400 has helped my sleep. Thanks!


Hi Madd;

According to the package insert, the 400 mg dose is FDA indicated for treatment of secondary amenorrhea for 10 days only. You have to scroll past all the black box warnings about provera and progestin, as well as possible side effects of prometrium (brand name progesterone) to get to the approved dosing.

The FDA approved use of prometrium covers "endometrial hyperplasia prevention, postmenopausal" using 200 mg at bedtime 12 days out of 28. Any other use of the drug is off label. That being said, prescribers use medicines off label all the time.

I've been taking 200 mg at bedtime every day (off label!) I'm scheduled to see a new FM MD later in the month, and will see what she suggests for dosing. Higher dosing for me will be a cost issue. My insurance does not cover transdermal estradiol or progesterone. I'm currently paying approx $36/month for progesterone 200 mg #30 using Good Rx. Not sure I can swing $72/month without cutting back on an equivalent monthly cost of supplements. :D
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