slacker wrote:I take my progesterone 200 mg at bedtime with water, approx 3 hours after eating. My levels tend to run low-ish but this dose of progesterone seems to be the maximum recommended.
maddanwill wrote:slacker wrote:I take my progesterone 200 mg at bedtime with water, approx 3 hours after eating. My levels tend to run low-ish but this dose of progesterone seems to be the maximum recommended.
Slacker, I am taking 400 mg of progesterone as prescribed by my doc. She said my progesterone/estrogen ratio was off. I do carry a gene that predisposes me to estrogen dominance. I read your post and was wondering who recommends 200 mg as being the max recommended dose? BTW the increase to 400 has helped my sleep. Thanks!
My problem is that my BHRT doctor has told me to take progesterone 2-3 hours after evening meal, just before going to bed with fatty food. The actual advice was to take it with a big bowl of full fat yoghurt as apparently the progesterone needs to "sit in fat" to be able to to be properly absorbed.
Absorption of micronized P was enhanced twofold in the presence of food.
Influence of food on bioavailability
When oral progesterone is taken with food instead of taken in a fasting state, it appears that maximal levels of progesterone and its overall bioavailability may be greatly improved. Measured with the unreliable method of RIA, peak levels of progesterone were increased by 5-fold and area-under-the-curve levels of progesterone by 2-fold when oral progesterone was taken with food. In this RIA study, a single dose of 200 mg oral progesterone in fasting and fed conditions resulted in peak levels of progesterone of 13.4 ng/mL and 69.5 ng/mL, respectively, and AUC0–24 levels of progesterone of 91.5 ng/mL and 182.5 ng/mL, respectively. Likewise however, a study using the reliable method of HPLC–MS/MS found that peak levels of progesterone were 69.7 to 89.2 ng/mL and AUC0–24 levels of progesterone were 111.6 to 125.9 ng/mL after a single dose of 200 mg oral progesterone with a high-fat, high-calorie meal. These data, which are fairly similar, indicate that the previous findings of the RIA study may not have been fully erroneous and may in considerable part have indeed represented actual levels of progesterone rather than those of its metabolites. On the basis of the HPLC–MS/MS study findings and previous studies using reliable methods, peak levels of progesterone when oral progesterone is taken with food may be on the order of 15- to 20-fold greater than when it is taken in a fasting state.
The apparent substantial improvement in progesterone levels and bioavailability when oral progesterone is taken with food may be due to enhanced lymphatic absorption, allowing oral progesterone to bypass some first-pass metabolism. In accordance, a related steroid medication, oral testosterone undecanoate in oil-filled capsules, is absorbed by the lymphatic system but must be taken with meals that contain at least a moderate or "normal" amount of fat for adequate bioavailability. Taking oral testosterone undecanoate with food has been found to increase peak testosterone levels by 16-fold and the overall bioavailability by 11-fold relative to when the medication is taken in a fasting state. Although the bioavailability of oral progesterone is greatly increased if it is taken with food, its overall bioavailability is still relatively low, even if measured using RIA.
Plumster wrote:And then there's anecdotal evidence: I can't sleep if I haven't eaten enough during the day. In fact, I often don't sleep well even if I have eaten enough. Last night, I ended up eating something light (a banana and two handfuls of a chickpea snack) at 10PM and took 200 mg oral progesterone and I slept soundly in a way I very, very rarely do. In fact, considering I generally have sleep issues and that my sleep was so good last night, I may need to incorporate a snack (a few nuts? 1 nut?) with taking progesterone at night. I'm still experimenting, but I will certainly prioritize good sleep over fasting. Has anyone else noticed a difference in sleep when taking progesterone with food?
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