Homocysteine was found to be significantly associated with cortical Aβ in people with low levels of omega-3s, even after controlling for E4 status in this study. And the kicker, not associated in those who had a high baseline index.
Cross-Sectional Associations of Total Plasma Homocysteine with Cortical β-Amyloid Independently and as a Function of Omega 3 Polyunsaturated Fatty Acid Status in Older Adults at Risk of Dementia.
https://www.ncbi.nlm.nih.gov/pubmed/29188863Exploratory analysis showed that homocysteine was however significantly associated with cortical Aβ in subjects with low baseline omega-3 index (< 4.72 %) after adjustment for Apolipoprotein E ε4 status (B-coefficient 0.041, 95 % CI: 0.017,0.066, p = 0.005, n = 10), but not in subjects with a high baseline omega-3 index (B-coefficient -0.010, 95 % CI: -0.023,0.003, p = 0.132, n = 66).
CONCLUSIONS: The role of n-3 PUFAs on the relationship between homocysteine and cerebral Aβ warrants further investigation.
For those of us with stubborn homocysteine levels, another area of focus to consider.