swanlzs wrote:Most carbs are whole grain
You may want to look into eliminating the whole grains. The big four that Dr Bredesen recommends avoiding are: grains, simple carbs, dairy, and lectins (lectins have been added since his book). Whole grains check two of those “boxes” they’re a grain and contain a lectin, a particularly insidious lectin, Wheat Germ Agglutinin (WGA). WGA is not a gluten, it’s found in the bran, so it is not found in white bread, only whole grain products. Unlike other lectins, WGA is very small, so even if you have a healthy, non-leaky gut, it can pass through the walls of the intestines. Many ills have been attributed to WGA, but of interest to ApoE4s:
1. It acts like insulin. Insulin is the “key” that unlocks the door of a cell to allow glucose (fuel) in. WGA will also fit into the “keyhole” but it just stays there, it doesn’t open the door. WGA blocks the insulin receptors of fat cells, muscle cells, and nerves/neurons. When WGA locks onto the insulin receptor of neurons, glucose can’t reach the neurons, adding to the cerebral glucose uptake impairment that afflicts all Alzheimer’s patients (remember Alzheimer’s is often called Type 3 Diabetes ). The brain demands a LOT of fuel, and if starved of fuel, brain cells die. ApoE4s seem to be predisposed to cerebral glucose uptake impairment (aka cerebral glucose hypometabolism), so avoiding anything that adds “fuel to the fire” seems to be a good idea to me.
2. WGA can promote inflammation by releasing free radicals which can thin the mucosal lining of the gut.
3. WGA crosses the blood-brain barrier, taking with it other substances to which it has bonded, additionally causing neurological problems.