TheresaB wrote:1. APOEε4s are ancestral genes, we should eat in a way that makes our genes comfortable. Our ancestors were the original humans who had evolved from the apes living in trees and eating a mostly vegan – tree leaves diet with occasional grubs and insects added in for animal protein. We were hunter-gathers, we wandered the savannah, ate whatever was available, when it was available, sometime hunted (meat) sometimes gathered (plants). Our DNA still thinks we are in the savannah. There’s a theory that thinks APOEε3 came about as an adaptation when more meat was introduced to the human diet.
Theresa, this is an old theory that doesn't hold up to current research. According to the primer, E3 appeared around 220,000 years ago. There is now evidence that early man controlled fire as early as 1 million years ago (mya) and was cooking food .5 mya. This is far prior to E3. Also, between 1.8 mya and .5 mya early man's brain size increased from 600 ml to 1,000 ml. So brain size increased during period of additional cooked foods...and likely meat, a very dense energy source. E3 is more likely a response to a new food source, like carbs. Why would man need a larger brain? To hunt for veggies?