Yes, a nice article, but I would argue with
Research indicates the E4 allele was selected against in human populations with a long historical exposure to agriculture, especially grain-based agriculture. For example, populations with the lowest E4 frequency include long-time agriculturalists such as Greeks (6.8%), Mayans (8.9%), and Arabs in northern Israel (4%), while long-time hunter-gatherers have a much higher E4 frequency: 40% among African Pygmies, 37% among both the Khoi San and Papuans, and 21% among the Inuit. So it appears that people who carry the E4 gene may not be evolutionarily well-suited to a high-carbohydrate diet.
The research that they point to is 20 years old. And while I agree that E3 allows higher carbs, it can't have anything to do with agriculture, since that did not start until much later than the E3 version. Maybe E2 could be, but not E3. I believe it was actually man's first access to tubers that provided the new carbs - toxic to humans in the old world, without first soaking for a long period to remove toxins. If you actually map out % E4, you will see that ALL of sub-sahara Africa has high E4, while the lowest occurs in the middle east, and it spreads from there. Places in the old world besides southern africa with high E4 are those areas hardest to get to from the middle east - ice-bound northern europe and Indonesia. The new world is much like the place where the population came from in the old world, except those areas with high native american %, since they tend to have low E4.
You do not have the required permissions to view the files attached to this post.