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Amy Berger blog - ApoE4 and Alzheimer's

Posted: Fri Aug 09, 2019 9:44 am
by DaleBru
FYI: Amy Berger wrote a book titled "The Alzheimer's Antidote: Using a Low-Carb, High-Fat Diet to Fight Alzheimer’s Disease, Memory Loss, and Cognitive Decline" in 2017.

Today she tweeted about a blog "Exploring the link between the ApoE4 gene and increased risk for Alzheimer’s" she wrote a few days ago:

I think it is an outstanding article with links to some important research. Here's a quote:
The APOE ε4 allele may not be inherently damaging but only in combination with a high-carbohydrate diet, which is damaging in itself and is likely to be a major contributor to the high risk of CAD [coronary artery disease], and possibly AD, in modern populations with or without the APOE ε4 allele.

Re: Amy Berger blog - ApoE4 and Alzheimer's

Posted: Fri Aug 09, 2019 11:24 am
by mike
Yes, a nice article, but I would argue with

Research indicates the E4 allele was selected against in human populations with a long historical exposure to agriculture, especially grain-based agriculture. For example, populations with the lowest E4 frequency include long-time agriculturalists such as Greeks (6.8%), Mayans (8.9%), and Arabs in northern Israel (4%), while long-time hunter-gatherers have a much higher E4 frequency: 40% among African Pygmies, 37% among both the Khoi San and Papuans, and 21% among the Inuit. So it appears that people who carry the E4 gene may not be evolutionarily well-suited to a high-carbohydrate diet.

The research that they point to is 20 years old. And while I agree that E3 allows higher carbs, it can't have anything to do with agriculture, since that did not start until much later than the E3 version. Maybe E2 could be, but not E3. I believe it was actually man's first access to tubers that provided the new carbs - toxic to humans in the old world, without first soaking for a long period to remove toxins. If you actually map out % E4, you will see that ALL of sub-sahara Africa has high E4, while the lowest occurs in the middle east, and it spreads from there. Places in the old world besides southern africa with high E4 are those areas hardest to get to from the middle east - ice-bound northern europe and Indonesia. The new world is much like the place where the population came from in the old world, except those areas with high native american %, since they tend to have low E4.


Re: Amy Berger blog - ApoE4 and Alzheimer's

Posted: Sun Aug 11, 2019 11:27 am
by laurie
Eating a diet rich in silica maybe more beneficial for people with the APOE-4 gene. Here is a write up about people in Nigeria who have the APOE-4 gene but lower rates of Alzheimer's. "the e4 allele in the Yoruba people was not significantly associated with AD or dementia283. " 283. Gureje, O., et al.; APOE e4 is not associated with Alzheimer’s disease in elderly Nigerians; Ann. Neurol.; Jan.; 59(1):182-185 (2006) This write up explains how silica is a protective factor for the Yoruba people. In this write up the author Dr. Crouse, presents data as to why this is the case and that high levels of silica in their drinking water and food is the reason.