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Creatine increase in PCC in early AD

Posted: Fri Aug 23, 2019 7:59 am
by Lulu
Hi there,

Curious, could there be negative implications to supplementing with creatine? I've been working out and looking to improve muscle mass, so I started taking creatine monohydrate a little while ago without doing any in depth research on it. I've been using it on and off, and just started researching it again and found an article that I found concerning.

The conclusion of the article states that there is an increase of creatine concentration in the posterior cingular cortex in early Alzheimer's disease.

Maybe bumping up the creatine is not such a good idea, I'm thinking. Any thoughts out there? Thanks!

https://www.alzheimersanddementia.com/a ... 52-5260(12)00222-1/pdf

Re: Creatine increase in PCC in early AD

Posted: Fri Aug 23, 2019 8:04 am
by Lulu
Ok, so for some reason the article does not come up when you click on it, but here is the conclusion:

Conclusions: An increased
Cr concentration in PCG may be associated with the development of AD,
reflecting the underlying neurodegenerative pathology and the disturbed
balance of energy supply and energy demand. The study also suggests
that combining information on changes of Cr levels and those of other
major metabolites can help improve AD identification.

Re: Creatine increase in PCC in early AD

Posted: Fri Aug 23, 2019 8:52 am
by SusanJ
Lulu wrote:Ok, so for some reason the article does not come up when you click on it


This site's software has problems with URLs that have parens in them.

Here is a working link to your article.

Re: Creatine increase in PCC in early AD

Posted: Fri Aug 23, 2019 9:45 am
by circular
Lulu wrote:Ok, so for some reason the article does not come up when you click on it, but here is the conclusion:

Conclusions: An increased
Cr concentration in PCG may be associated with the development of AD,
reflecting the underlying neurodegenerative pathology and the disturbed
balance of energy supply and energy demand. The study also suggests
that combining information on changes of Cr levels and those of other
major metabolites can help improve AD identification.

This may be a chicken and egg thing. It's possible that some other pathology in the Alzheimer's brain is causing the accumulation, rather than creatine causing the pathology. I haven't looked into it for a while, but I think there have also been suggestions that creatine is good for the brain. You might search the forum for creatine. If it didn't make me so bloated I would probably take it.

Re: Creatine increase in PCC in early AD

Posted: Thu Aug 29, 2019 11:34 am
by Hboroughs
Creatine is often recommended for those with MTHFR defects as it is a large user of methyl donors. In this way supplementation preserves methyl groups for other uses. I have tried it with the result being wicked insomnia. Choline supplementation does the same thing to me. I am not sure why this is, but sleep trumps supplements all day long!

Re: Creatine increase in PCC in early AD

Posted: Sun Sep 01, 2019 10:15 am
by Michae_M
On balance, I would not think that these complicated imaging studies should be viewed to suggested cause and effect. Here are two papers on the topic of creatine that you may find helpful.

https://jissn.biomedcentral.com/article ... 017-0173-z
https://www.sciencedirect.com/science/a ... 6518300263