I have been confused on this issue as well. I do want to lower my homocysteine from 9.8, but I have read that choline intake raised insulin resistance (appears to be an inconsistent result according the studies Julie cited), but also I think I have read that choline supplementation may raise cholesterol levels. Since high LDL is a problem for me (both LDL-C and LDL-P are high), I am at a crossroads. Which is more concerning...high cholesterol or high homocysteine? My second question has to do with which methyl donor to use when I do supplement if lowering homocysteine without raising other biomarkers is the goal. So do I take choline, or TMG, or PC, or betaine, or a little of each if meat intake is low? Right now, I switch back and forth, but I don't have any confidence that I know what I am doing. Each morning, I have numerous supplement bottles to choose from and I am always wondering if what I am taking is more harmful or helpful.
I am postmenopausal, and regarding this issue, genetics is working against me. Thank you for your insights.
E3/E4, My mother was diagnosed with AD at age 73.