And why is glucose divided by 18 before dividing that by the ketone level?
aphorist wrote:I'd personally like to know the difference in flux in muscle/brain at various GKI levels, because why is the magic ratio 1.0 and not 1.1 or 0.9 or whatever? IDK. Seems like it's just some cute simple metric.
aphorist wrote:It's just a simple ratio that some person can claim they 'invented' or that they are some 'pioneer' in identifying. Assuming you are not in diabetic ketoacidosis or taking exogenous ketones, what matters most is the absolute level of ketones, such that they are available as an energy substrate and your body has undergone a metabolic shift.
mike wrote:I would disagree with this a bit. The value of one is where ketones = glucose. Getting ketones > glucose means GKI < 1. The body will use glucose before ketones if it has a choice (mostly to clear it), so to get to a point where your body is properly using ketones, you want to starve the body of glucose. This is particularly important for diabetics - I constantly run over .5 for ketones, but it is no where near as effective because of my high sugars. One needs to eat mostly fat to keep below 1 while eating Generally a GKI of 3 is considered the starting range for nutritional ketosis. Getting t.o under 1 and you start getting increasing autophagy and often see shrinkage of cancer.
If you tested the average person their GKI is probably infinite because their BHB is 0. I don't think Seyfried would distinguish between 0.9 and 1.1. There is likely a difference between 1, 5, 50, 500 & infinity. For example, glucose of 80 and ketones of 0.5 would be a GKI of ((80/18)/.05)=8.9 while 80 and 2 would be 2.2.
Tincup wrote:Also in the cancer realm, the concept is to get the glucose low, not just the BHB high. Not saying this is best for cognition. A number close to 1 would be glucose of 60 and BHB of 3 = 1.1.
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