Risks of dampening the inflammatory response?

Alzheimer's, cardiovascular, and other chronic diseases; biomarkers, lifestyle, supplements, drugs, and health care.
Jafa
Senior Contributor
Senior Contributor
Posts: 192
Joined: Fri Dec 16, 2016 12:46 am

Risks of dampening the inflammatory response?

Postby Jafa » Tue Dec 17, 2019 11:42 pm

Like most people on the forum I follow a lot of Bredesen’s protocol re supplements taking Theracurmin, resveratrol and omega 3’s, with the aim of suppressing overactive inflammation. Recently my family were ill with some sort of cold virus which gave them minor symptoms for a few days. However, when I caught what initially appeared to be the same virus I became much more unwell, was febrile for days, had absolutely no energy and was diagnosed by my GP with pneumonia. The prescribed antibiotics didn’t really make much difference for several days so it seems as though it was viral. It’s taken me a month to recover my energy levels and ability to exercise.

My CRP is normally <1 and was 92 while unwell, and my usual mild neutropaenia resolved, the count climbing from 1.2 to over 6. I’ve not yet repeated those bloods.

I’ve been pondering...is there a risk in biohacking the inflammatory response? What if you need those free radicals to wipe out the attacking pathogens? Might we risk losing a pitched battle while we endeavour to play the long game?

User avatar
slacker
Mod
Mod
Posts: 2029
Joined: Wed Aug 03, 2016 6:20 pm
Location: Kentucky

Re: Risks of dampening the inflammatory response?

Postby slacker » Wed Dec 18, 2019 4:43 am

Interesting question. I suspect the answer is that no one knows. Immune suppressant treatments for rheumatoid arthritis and some cancers certainty increase risk for infection. These therapies are balancing benefits and risks. Are the combinations of anti inflammatory supplements we are taking strong enough to weaken our immune system rather than just calm down inflammation? Was your bad infection just bad luck of the draw? I too recently had a bad cold that took a long time to go away - it was not nearly as severe as yours and I never went to the doctor. However, I spoke with several other people in my community who had similar infections that seems to linger on.
Slacker
E4/E4

User avatar
SusanJ
Senior Contributor
Senior Contributor
Posts: 2772
Joined: Wed Oct 30, 2013 7:33 am
Location: Central Florida

Re: Risks of dampening the inflammatory response?

Postby SusanJ » Wed Dec 18, 2019 6:45 am

Jafa wrote:I’ve been pondering...is there a risk in biohacking the inflammatory response? What if you need those free radicals to wipe out the attacking pathogens? Might we risk losing a pitched battle while we endeavour to play the long game?


I think slacker's analogy is an important one. We know what using the sledgehammer approach of the RA biologics will do to people: infections and cancer. My dad succumbed to pneumonia and had been on Remicade for several years. Did it play a role in his inability to fight pneumonia? There's no doubt it did.

And yes, there are concerns about too many antioxidants messing with free radicals that effect our immune cell signaling. I wrote about it a while back. Antioxidants, ROS, glucose metabolism, CAD and RA.

In the end, we all walk a fine line in any biohacking we do through supplements. Think we'll find over time there might be one dose for prevention and one dose for treatment for these types of supplements. Bredesen's experience has been in treating those with cognitive impairment, so we're just extrapolating at the moment for prevention. Personally, I've cut back on curcumin and fish oil over what I took a couple years ago and dropped some (like quercetin) as I've healed my gut and changed my diet.

User avatar
slacker
Mod
Mod
Posts: 2029
Joined: Wed Aug 03, 2016 6:20 pm
Location: Kentucky

Re: Risks of dampening the inflammatory response?

Postby slacker » Wed Dec 18, 2019 12:29 pm

As I become "well", I plan to slowly cut back on as many supplements as possible. My FM MD supports this. The rub is determining what is "well!" :lol:
Slacker
E4/E4

zc_hl
Contributor
Contributor
Posts: 40
Joined: Fri Aug 16, 2019 2:29 am

Re: Risks of dampening the inflammatory response?

Postby zc_hl » Thu Dec 19, 2019 12:13 am

Hi Jafa,

If you have some time, I would advise you to read about the Marshall pathogenesis hypothesis which is totally on topic: https://mpkb.org/home/patients/pathogenesis_overview

By the way, amyloid-β is an anti-microbial peptide (https://pubmed.ncbi.nlm.nih.gov/2950453 ... -evidence/):

"Recent evidence indicates a role for Aβ as an antimicrobial peptide (AMP), a class of innate immune defense molecule that utilizes fibrillation to protect the host from a wide range of infectious agents. In humans and in animal models, infection of the brain frequently leads to increased amyloidogenic processing of the amyloid-β protein precursor (AβPP) and resultant fibrillary aggregates of Aβ."

Jafa
Senior Contributor
Senior Contributor
Posts: 192
Joined: Fri Dec 16, 2016 12:46 am

Re: Risks of dampening the inflammatory response?

Postby Jafa » Fri Dec 20, 2019 12:09 am

Thanks. It’s really hard to know sometimes where the sweet spot is with respect to the interventions we embark on, particularly if the subject of our n=1 trials has yet to display “disease”. I’m going to review my stack, will continue those supplements which help with sleep, but maybe reduce, pulse or cycle through the anti-oxidants. Ben Lynch recommended this approach in his “Dirty Genes” book, and Chris Masterjohn regularly comments that the dose-response curve for most biohacking interventions is “U” shaped, with poorer outcomes present both sides of the optimum.

User avatar
CarrieS
Support Team
Support Team
Posts: 398
Joined: Thu Jun 22, 2017 12:21 pm

Re: Risks of dampening the inflammatory response?

Postby CarrieS » Mon Dec 23, 2019 7:50 am

Jafa wrote:Like most people on the forum I follow a lot of Bredesen’s protocol re supplements taking Theracurmin, resveratrol and omega 3’s, with the aim of suppressing overactive inflammation. Recently my family were ill with some sort of cold virus which gave them minor symptoms for a few days. However, when I caught what initially appeared to be the same virus I became much more unwell, was febrile for days, had absolutely no energy and was diagnosed by my GP with pneumonia. The prescribed antibiotics didn’t really make much difference for several days so it seems as though it was viral. It’s taken me a month to recover my energy levels and ability to exercise.

My CRP is normally <1 and was 92 while unwell, and my usual mild neutropaenia resolved, the count climbing from 1.2 to over 6. I’ve not yet repeated those bloods.

I’ve been pondering...is there a risk in biohacking the inflammatory response? What if you need those free radicals to wipe out the attacking pathogens? Might we risk losing a pitched battle while we endeavour to play the long game?


Hi Jafa, This article came through my email this morning and seemed relevant to your post so I thought I'd share. Carrie
https://www.mindbodygreen.com/articles/ ... 2_20191223
APOe4/4
Functional Medicine Certified Health Coach
National Board Certified Health & Wellness Coach
Certificate for Reversing Cognitive Decline for Coaches (FMCA)
Certified Fermentationist


Return to “Prevention and Treatment”

Who is online

Users browsing this forum: No registered users and 7 guests