xactly wrote:I took Metformin briefly earlier this year. I'm a healthy older adult without metabolic disorder or diabetes. I discontinued use after a couple of months when Peter Attia shared research showing Metformin blunts the positive effects of exercise in healthy people. Interestingly, and possibly related to a placebo/nocebo response, I felt stronger after stopping the Metformin, and I experienced delayed-onset muscle soreness for the first time in many months. That made me feel Metformin was, indeed, blocking hypertrophy.
SoccerMom wrote:Trying to do everything I can to stay healthy and avoid the same fate as my parents. My dad died last year at 67 from Lewy Body Dementia and my mom has early Alzheimer's at age 68 (she's a 4/4). They both smoked and drank, didn't exercise much, and ate whatever they wanted.
I'm almost 45 (I'm a 3/4) and exercise daily and have a pretty clean diet and excellent BMI and health. I don't drink or smoke. I know Metformin has been used safely for decades, and considering asking my doctor about taking it for longevity/health. Is anyone doing this and did your doctor prescribe it?
SoccerMom wrote:For now I will wait for more conclusive evidence that the benefits outweigh the risks for healthy people.
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