If anyone is looking for an alternative to Metformin for increasing longevity you should consider drinking silica rich mineral water. It is more effective and safer than taking something that is not made by the body or essential to the body. Silica is an essential nutrient. Drinking silica rich mineral water also decreases your risk of Alzheimer's. If you are familiar with Blue Zones of the world all five have drinking water high in silica. My husband Dennis N Crouse is a scientist who is retired and spent his career in the field of environmental toxins. Since retiring he has continued his work because his mother has Alzheimer's. He has now written 2 books the second book which was just updated is 'Silica Water the Secret to Blue Zone Longevity in the Aluminum Age'. The book is available on Amazon.
Here is a link to the Alzheimer's chapter in this book. http://prevent-alzheimers-autism-stroke.blogspot.com/2019/01/aluminum-as-causal-factor-of-alzheimers.html
Here is a description of the book "Research on the world's six blue zones, where people live longer than normal, reveals high levels of dissolved silica in their drinking water. This book describes this research and explains why dissolved silica is a causal factor of longevity. Learn how silica water prevents, and heals the following conditions and terminal diseases: Alzheimer's, Atherosclerosis, Heart Disease, Autism, Multiple Sclerosis, Osteoporosis, Parkinson's, and Seizures.
After publishing this book in 2018, when only 5 blue zones had been identified by demographers, two papers were published fully describing a sixth blue zone. This new data was remarkable as, after examining all variables that could account for extreme longevity, the demographers found only high levels of silica in drinking water were unique to this blue zone as compared with the surrounding areas that did not have extreme longevity. This new data is incorporated in the updated second edition of this book.
Dr. Crouse majored in biochemistry at Harvard College and has a Ph.D. in chemistry from Harvard University."
"True prevention is only possible by first discovering the cause of a disease such as Alzheimer's."
Dennis N Crouse