Short&Right wrote:I've really been enjoying this site recently and figured this might be my one opportunity to contribute something here, as I'm an anesthesiologist. Propofol is probably the most commonly used drug in all of anesthesia. It is quite versatile and can be used for anything from light "conscious sedation" to general anesthesia. When used for sedation for procedures like colonoscopies it is very much a "titrate to effect" kind of drug, i.e. one person might be adequately sedated at dose x, but a 2nd person may require 1.5x for the same effect. It is very rapidly acting and we constantly adjust the dose to achieve the desired degree of sedation. It also typically wears off very quickly which is why it is so popular for quick procedures like a colonoscopy. One thing to keep in mind is that it is used as a continuous infusion for procedures like this so the longer the procedure the higher the total dose. So comparing total doses between procedures has very limited value.
There are definitely drug interactions between propofol, gabapentin, and clonazepam. Sedatives like clonazepam(and all other benzodiazepines) have an additive effect with propofol reducing the dose needed for a given effect. In fact we often deliberately take advantage of these interactions so there is nothing inherently dangerous about this combination.
It is difficult to know exactly what caused the OPs negative experience. But if I were to hazard a guess it was probably some combination of sleep deprivation, dehydration from the colon prep, and interactions with the different drugs used. The mental state prior to sedation probably does have some bearing on emotionality with emergence from anesthesia but for obvious reasons this is a little difficult to study accurately.
Hi Short&Right-- thanks so much for sharing some of your insight on this subject and for ultimately deciding to contribute! The ApoE4.info site is so rich with valuable information because of the contributions that professionals like yourself offer. Welcome to the community! I'm hopeful you'll continue to connect and share.
Not sure if you've familiarized yourself with the site, but we typically direct new contributors to the primer
, which offers a lovely overview of the science of ApoE4 and other preventative details written by Stavia (another member physician who is homozygous for the ApoE4 allele). I'm a big fan of the wiki page
because it is chocked full of really useful facts that are often missed by other search engines. Lastly, if you are inclined please feel free to introduce yourself
and share a little about your own journey.
With hope for health and prosperity in the new year!