adventure wrote:I have severe osteoarthritis of my left hip but I am afraid to have surgery. I am concerned about the possibility of developing Postoperative Cognitive Dysfunction (POCD). I have an ApoE4 gene which I know increases my risk.
Happy New Year, adventure!adventure wrote:I have severe osteoarthritis of my left hip but I am afraid to have surgery. I am concerned about the possibility of developing Postoperative Cognitive Dysfunction (POCD). I have an ApoE4 gene which I know increases my risk.
Three hundred patients for hip joint replacement and 51 nonsurgical controls aged 60 yr or older were studied in a prospective observational clinical trial. All study participants and controls completed a battery of eight neuropsychological tests before surgery and at 7 days, 3 months, and 12 months afterwards. Preoperative cognitive status was assessed using preexisting cognitive impairment (PreCI) defined as a decline of at least 2 SD on two or more of seven neuropsychological tests compared to population norms. POCD and cognitive decline were assessed using the reliable change index utilizing the results of the control group.
Results:: PreCI [pre-operative cognitive impairment] was classified in 96 of 300 (32%) patients (95% CI, 23 to 43%). After surgery, 49 of 286 (17%) patients (95% CI, 13 to 22%) and 27 of 284 (10%) patients (95% CI, 6 to 13%) demonstrated POCD at 7 days and 3 months, respectively, while 7 of 271 (3%) patients (95% CI, 1 to 4%) demonstrated cognitive decline at 12 months. Patients with PreCI had a significantly increased incidence of POCD at 7 days and 3 months and cognitive decline at 12 months.
Return to “Prevention and Treatment”
Users browsing this forum: No registered users and 15 guests