circular wrote:he did a recent podcast on apoe4. You might want to listen to it or read the transcript for his thoughts. He mentions small dense LDL from animal meat being particularly bad for e4. Interestingly, he's also said that higher sdLDL propensity is something people are born with and doesn't change much if at all in their life, so it only needs to be tested once. [EDIT: I got sdLDL confused with Lp(a) ... sdLDL does get retested to keep track, but not normally Lp(a) which is genetically determined.] So here I am with 3/4 and low sdLDL, even when eating a fair amount more animal meat than he recommends. Given, he probably recommends low animal protein for more reasons than just sdLDL (MTOR, IGF1 ...), but sdLDL is something you can measure that he strongly believes links e4 to Alzhiemer's.
His program overall seems to dial down inflammation, which of course is good for preventing all chronic diseases, but so does the Mediterranean diet.
Thanks @circular - I read this and appreciate you following up with the clarification of sdLDL vs. Lp(a). I specifically want to ask you and readers here How do you/we measure inflammation? because this is where the rubber meets the road on whether these diets (any of them) work or not for our particular approaches if we believe that inflammation = increase in cardiovascular risk & Alzheimers.
circular wrote:These days, that is recently, I'm worrying less about the details of diet and supplements (not to say not focused on them) in favor of being far more committed to a strong meditation practice.
Wow this is huge that you mention this, I want to share with you and this group this particular clinical work that comes up with a reason why "contemplative acts" have an actual impact on our wellbeing. Whether it's meditation or yoga or whatever. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189422/, it may be worthy of its own post on here if it hasn't already been discussed. It talks specifically about how breathing focus (which happens as a byproduct of contemplative acts) stimulates the vagal nerve which reduces our overall stress/inflammation in our system.
What this means is we might have a clinical reason why meditation and contemplative acts have a physiological impact on our actual biology. So your hunch may actually be backed up by science. I really think you will appreciate this paper if you can plow through it. thanks for taking the time to comment.