John34 wrote:Hi everyone,
...Any comments on these or any other (even more comprehensive) options for me to consider would be very much appreciated. If this question has been asked and answered before please forgive me for my inability to locate the answer. If so, can you kindly point me in the right direction or provide me with a link?...
John
Hi John,
No apologies needed for difficulty finding topics! In a forum with 73,000+ posts and counting, it can be challenging. FWIW, an actual Google search of a topic + "apoe4" sometimes turns up forum topics, The closest thing to a Google search on our forum is to use the magnifying glass icon in the upper right, near your user name. Click on that and you'll go to a Search page. You can put in key words and just hit "search" or narrow the search by Topic Titles, and other fields.
Here's our how-to wiki on
Searching the site for informationHere are the search results for "Sinclair + insidetracker"; you can click on the "jump to post" link in the lower right of each preview to read the entire post, and then use the back arrow on your computer to return to search results:
Sinclair: InsidetrackerIf you want to get an idea of how your cognition is doing in addition to biomarkers, you may want to check out a new online study. You can find information about it here:
APT Webstudy Welcome Full disclosure: I am on the Research Participant Advisory Board for the Alzheimer's Clinical Trial Consortium, a group of dozens of research centers which is coordinating the APT Webstudy, although I am not in any ACTC-sponsored clinical trial or study. My understanding is that participants are notified of their results after each testing period, which occurs every three months.
I noticed in your previous posts that you, like many of us, saw those risk estimates of "3x" the risk of AD with ApoE 3/4. Those estimates are works in progress and tend to ignore more recent (2019) estimates given at the Alzheimer's international Conference that 30% of AD cases may be preventable with aggressive management of risk factors such as excessive alcohol use, smoking, moderate to severe traumatic or repetitive brain injuries, diabetes, high blood pressure, coronary artery disease, and use of exercise, diet, cognitive and social stimulation, sleep and stress management.
A 2017 meta-analysis of four large cohorts over time resulted in this statement, used in a study I was in for people with ApoE 3/4 and 4/4:
The Generation Study elected to disclose the following “lifetime” risks of MCI or dementia to its potential participants: 30%–55% for individuals with APOE-e4/e4; 20%–25% for individuals with APOE-e3/e4 and -e2/e4 (with a note that risk might be lower for those with APOE-e2/e4); and 10%–15% for individuals with APOE-e3/e3, -e3/e2, and -e2/e2 (with a note that risk might be lower for those with APOE-e2/e3 and -e2/e2). These values are consistent with our findings, but use round numbers for intelligibility, and broader ranges to reflect statistical and other sources of uncertainty
https://journals.plos.org/plosmedicine/ ... 254#sec019Keep up posted if you find good sources of personalized assessments and recommendations.