Rainbow wrote:Most notably, I seem to have an elevated heart rate, insomnia, and some chest discomfort while running (three to five miles, three or four days a week).
SusanJ wrote:I don't know the amounts of each you are taking, but excess folate can certainly lead to insomnia, and most likely your elevated heart rate. I'd back that off first and see where you land on your symptoms.
Rainbow wrote:The methyl folate is 800 mcg, the B12 is 1000 mcg, the P5P is 20 mg and the creatine is 5 g. The phosphatidylcholine is specified as 650 mg "phospholipid complex". All daily.
SusanJ wrote:My own experience has been that I needed to adjust folate down as I added other methylation support. With that much creatine and PC, you might be ending up with excess SAMe from folate, because creatine and PC are reducing the need for the folate/SAMe in supplying the major methyltransferases PEMT and GAMT. SAMe then ends up being available to push other pathways.
I wish there was a simple formula with methylation problems, but there isn't. Just keep playing around with the amounts. Personally, I'd reduce the creatine next after a couple weeks of reduced folate if your symptoms don't resolve satisfactorily.
WillC wrote:Can you explain creatine, I had no idea it was used for anything but weight lifting?
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