Selenium:Mercury Ratio in Fish

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circular
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Selenium:Mercury Ratio in Fish

Postby circular » Thu Apr 22, 2021 10:27 pm

I’ve become less worried about eating a wider variety of fish since reading about the selenium:mercury ratio, but I wonder what others think. See http://net-effects.und.edu/pdfs/Selenium-Mercury.pdf

There was also a paper showing that mercury, even in e4s, didn’t counteract the benefits of fish consumption. I need to take a closer look at that and can’t get my hands on it just now.
ApoE 3/4 > Thanks in advance for any responses made to my posts.

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SusanJ
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Re: Selenium:Mercury Ratio in Fish

Postby SusanJ » Sat Apr 24, 2021 7:38 am

circular wrote:I’ve become less worried about eating a wider variety of fish since reading about the selenium:mercury ratio, but I wonder what others think.


Interesting. Found a couple of references with a quick search. Seems like it has some science to back it up.

Mercury Toxicity and the Mitigating Role of Selenium - https://link.springer.com/article/10.10 ... 008-0204-y
Mercury: Selenium interactions and health implications - https://www.researchgate.net/publicatio ... plications

circular
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Re: Selenium:Mercury Ratio in Fish

Postby circular » Tue Apr 27, 2021 6:42 pm

SusanJ wrote:
circular wrote:I’ve become less worried about eating a wider variety of fish since reading about the selenium:mercury ratio, but I wonder what others think.


Interesting. Found a couple of references with a quick search. Seems like it has some science to back it up.

Mercury Toxicity and the Mitigating Role of Selenium - https://link.springer.com/article/10.10 ... 008-0204-y
Mercury: Selenium interactions and health implications - https://www.researchgate.net/publicatio ... plications

Thanks, and here are some more links:

Association of Seafood Consumption, Brain Mercury Level, and APOE ε4 Status With Brain Neuropathology in Older Adults (286 autopsied brains, food frequency questionaire, old, largely non-Hispanic white cohort)
Conclusions
In cross-sectional analyses, moderate seafood consumption was correlated with lesser burden of brain Alzheimer disease neuropathology in APOE ε4 carriers. Although seafood consumption was correlated with higher brain levels of mercury, these levels were not correlated with brain neuropathology

Rethinking mercury: the role of selenium in the pathophysiology of mercury toxicity (review of 117 culled references)
Selenium supplementation has been shown to restore selenoprotein function and reduce the toxicity of mercury, with several significant limitations including: the form of mercury (methylmercury toxicity is less responsive to amelioration) and mercury dose. [The study above suggests the possibility that methylmercury in the brain may be responsive enough given adequate selenium; ie, a robust selenium:mercury ratio?]

Conclusions: The interaction with selenium is a central feature in mercury toxicity. This interaction is complex depending on a number of features such as the form of mercury, the form of selenium, the organ and dose. The previously suggested “protective effect” of selenium against mercury toxicity may in fact be backwards. The effect of mercury is to produce a selenium deficiency state and a direct inhibition of selenium’s role in controlling the intracellular redox environment in organisms. Selenium supplementation, with limitations, may have a beneficial role in restoring adequate selenium status from the deficiency state and mitigating the toxicity of mercury.

Selenium modifies associations between multiple metals and neurologic symptoms in Gulf states residents (blood cadmium, lead, total mercury, manganese, and selenium in 1007 Gulf state residents)
Blood selenium modified associations between cadmium, lead, and mercury and neurologic symptoms …

Although blood mercury was not associated with neurologic symptoms overall, we observed a suggestive inverse interaction between higher levels of selenium and the highest quartile of mercury…

Among those with lower selenium, positive associations for all outcomes were driven by cadmium and lead. In the higher selenium group, mercury drove inverse associations… [I'm having trouble wrapping my brain around that last statement.] …

In both single chemical and mixture analyses, we found that increasing levels of blood cadmium and lead were associated with a higher prevalence of CNS and PNS symptoms, respectively. While manganese and selenium were not consistently independently associated with outcomes, selenium modified associations between cadmium, lead, and [total] mercury with neurologic endpoints. These findings indicate that general population levels of metals may be related to subclinical neurotoxicity and future studies should consider effect heterogeneity by concomitant exposures such as selenium.
ApoE 3/4 > Thanks in advance for any responses made to my posts.

laurie
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Re: Selenium:Mercury Ratio in Fish

Postby laurie » Wed May 05, 2021 7:10 am

Here is a graph on the amount of mercury and selenium in fish.
mercury selenium in fish.jpg


If you are going to supplement to remove mercury, the form of selenium you need is L-selenomethionine. My husband who is a chemist has an evidence based write up. "It has been demonstrated that targeted detox of humans being chronically exposed to mercury is possible by taking 100mcg of selenomethionine daily for twelve weeks. The group being supplemented with selenomethionine had significantly enhanced urinary excretion of mercury5. In those with mercury induced selenium deficiency it may take on average 2 - 4 weeks to first restore the body’s selenium reserves before enhanced mercury excretion is observed (Figure 1)Here is a link." 5) Li, Y-F, et al.; Organic selenium supplementation increases mercury excretion and decreases oxidative damage in long-term mercury exposed residents from Wanshan, China; Environ. Sci. Technol.; 46:11313-18 (2012) http://prevent-alzheimers-autism-stroke.blogspot.com/2019/07/mercury-detox-using-selenium-method.html
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