Dr. Bredesen and others recommend a diet that “is a largely plant-based diet with an emphasis on vegetable”. I’ve been searching but can not locate the “why” for this recommendation. Is there something in plants we can not get from an animal-based diet or is there something in an animal-based diet we want to avoid?
I would appreciate any insight into the why.
Thanks
Plant-based diet recommendation
Re: Plant-based diet recommendation
Hi waaeaa, Welcome.
I think a lot of the emphasis is on enabling your body to engage in repair as opposed to growth. Animal protein tends to stimulate growth more than plant protein does. Also, plants provide many phytochemicals which are beneficial. For those of us with at least one copy of APOE4, it seems that minimizing saturated fat intake might also be beneficial. Look up articles on mTOR and on autophagy and I think you will find many explanations. Oh, also the care and feeding of beneficial gut bacteria which depend upon prebiotics (fiber and such) found in plants. Lots of material to read on this website. Good luck.
I think a lot of the emphasis is on enabling your body to engage in repair as opposed to growth. Animal protein tends to stimulate growth more than plant protein does. Also, plants provide many phytochemicals which are beneficial. For those of us with at least one copy of APOE4, it seems that minimizing saturated fat intake might also be beneficial. Look up articles on mTOR and on autophagy and I think you will find many explanations. Oh, also the care and feeding of beneficial gut bacteria which depend upon prebiotics (fiber and such) found in plants. Lots of material to read on this website. Good luck.
Re: Plant-based diet recommendation
What? There's plenty out there!waaeaa wrote: I’ve been searching but can not locate the “why” for this recommendation.
Post Publish edit: And what Whatnow said is correct also.
First of all, there's the strong gut-brain connection and maintaining a healthy gut relies strongly on plant based foods. You should read from our own wiki
Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs)
https://wiki.apoe4.info/wiki/Gut-Brain_ ... (gut_bugs)
There are also anti-inflammatory, adaptogenic (stress lowering), mitochondrial, vasodilation, oxygenation, antioxident, amyloid clearance, and more, benefits. Admittedly, just because it's a plant doesn't mean it's beneficial, I've had to eliminate certain plant foods (lectins) to reduce my inflammatory markers. But many plants offer superfood benefits.
Also remember as ApoE4s, we're the ancestral gene. It was only 400,000 years ago that man started to hunt large game on a regular basis. Before that humans were foragers and scavengers subsisting mainly on gathering plants, insects, small animals. Early humans ate a varied, plant-based diet, that's the diet our gene yearns for.
Here's just A FEW references on plant food/derivative substances and their benefits:
Neuroprotective Herbs for the Management of Alzheimer’s Disease
https://www.mdpi.com/2218-273X/11/4/543 ... KxyT1N1TTE#
Adding a blend of spices to a meal may help lower inflammation
http://www.sciencedaily.comireleases/20 ... 115627.htm
Root bacterium to fight Alzheimer's
http://www.sciencedaily.com/releases/20 ... 120039.htm
Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease
https://www.frontiersin.org/articles/10 ... 19024/full
Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions
https://www.frontiersin.org/articles/10 ... 04462/full
The protective effects of polyphenols on Alzheimer's disease: A systematic review
https://alz-journals.onlinelibrary.wile ... 018.09.002
Dietary Polyphenols, Mediterranean Diet, Prediabetes, and Type 2 Diabetes: A Narrative Review of the Evidence
https://www.hindawi.com/journals/omcl/2017/6723931/
Phytochemicals and cognitive health: Are flavonoids doing the trick?
https://www.sciencedirect.com/science/a ... via%3Dihub
Health benefits of olives and olive oil
https://www.sciencedaily.com/releases/2 ... 161025.htm
Olive-Oil-Derived Oleocanthal Enhances β‑Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In Vitro and in Vivo Studies
https://pubs.acs.org/doi/10.1021/cn400024q
Neuroprotection with Natural Antioxidants and Nutraceuticals in the Context of Brain Cell Degeneration: The Epigenetic Connection
https://pubmed.ncbi.nlm.nih.gov/31789133/
Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway
https://www.sciencedirect.com/science/a ... via%3Dihub
Natural Products as Modulators of Sirtuins
https://www.mdpi.com/1420-3049/25/14/3287
More Flavonol, Less Alzheimer's
https://www.medpagetoday.com/neurology/ ... ease/84603
More berries, apples and tea may have protective benefits against Alzheimer's
https://www.sciencedaily.com/releases/2 ... 121701.htm
Medicinal Plants for Cardiovascular and Neurodegenerative Aging-Related Diseases: From Bench to Bedside
https://www.frontiersin.org/articles/10 ... 85155/full
Long-term dietary flavonoid intake and risk of Alzheimer disease and related dementias in the Framingham Offspring Cohort
https://academic.oup.com/ajcn/article/112/2/343/5823790
Is Cocoa Good for the Brain?
https://www.news-medical.net/health/Is- ... Brain.aspx
Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults
https://www.nature.com/articles/s41598-020-76160-9
The Effects of Flavonoids in Cardiovascular Diseases
https://www.mdpi.com/1420-3049/25/18/4320
Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?
https://www.mdpi.com/1420-3049/25/13/3060
Molecular Level Insight Into the Benefit of Myricetin and Dihydromyricetin Uptake in Patients With Alzheimer’s Diseases
https://www.frontiersin.org/articles/10 ... 01603/full
Nootropics, Functional Foods, and Dietary Patterns for Prevention of Cognitive Decline
https://www.sciencedirect.com/science/a ... 3768000198
Dietary flavonols and risk of Alzheimer dementia
https://n.neurology.org/content/94/16/e1749
Cocoa flavanols boost brain oxygenation, cognition in healthy adults
https://www.sciencedaily.com/releases/2 ... 092154.htm
Citrus Polyphenols in Brain Health and Disease: Current Perspectives
https://www.frontiersin.org/articles/10 ... 40648/full
Interaction of Cinnamaldehyde and Epicatechin with Tau: Implications of Beneficial Effects in Modulating Alzheimer's Disease Pathogenesis
https://content.iospress.com/articles/j ... /jad122113
Cinnamic Acid Derivatives and Their Biological Efficacy
https://www.mdpi.com/1422-0067/21/16/5712
Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies
https://www.mdpi.com/2072-6643/13/2/537
The Benefits Of Broccoli Sprouts In TBI And Other Neurodegenerative Conditions
https://www.prohealth.com/library/benef ... ions-89704
Antioxidant Activity of Polyphenolic Plant Extracts
https://www.mdpi.com/2076-3921/9/1/19
-Theresa
ApoE 4/4
ApoE 4/4
Re: Plant-based diet recommendation
waaeaa wrote:Dr. Bredesen and others recommend a diet that “is a largely plant-based diet with an emphasis on vegetable”. I’ve been searching but can not locate the “why” for this recommendation. Is there something in plants we can not get from an animal-based diet or is there something in an animal-based diet we want to avoid?
I would appreciate any insight into the why.
Thanks
I think this is generally true, and our need to address repair is urgent, but I also think that quelling growth factors can easily go too far. Even Dr. Bredesen's theory maintains that we need a balance of growth and repair in the brain. Now just where to draw the line as far as animal protein amounts that trigger growth factors (for those eating it) can be tricky. I've come to think that there shouldn't even be a general recommendation for dietary protein amounts, and that it should be based on individual clincial status like everything else.Whatnow wrote: I think a lot of the emphasis is on enabling your body to engage in repair as opposed to growth.
I personally don't even want to think about a diet without any or too low in animal protein, not for aethestic or philosophical reasons (although we need to consider this and choose responsible sources when possible), but because I appreciate that animal protein provides better amounts of extremely important nutrients than plants do in its place. The good news is that it doesn't really push out any plant foods, which can still be optimized for their many complementary benefits.
Last edited by circular on Sun May 16, 2021 5:13 pm, edited 1 time in total.
ApoE 3/4 > Thanks in advance for any responses made to my posts.
Re: Plant-based diet recommendation
Yes, of course you're correct about the need for balance. In my particular case (and I think for many others in Western countries like the USA) I could easily see that I was probably overdoing the animal protein in my diet. Also, as a type 2 diabetic, I find many vegetable protein sources come with more carbs than I want.
Re: Plant-based diet recommendation
Theresa, you're a machine! What an amazing collection of references. Deep bow.What? There's plenty out there!
Post Publish edit: And what Whatnow said is correct also.
First of all, there's the strong gut-brain connection and maintaining a healthy gut relies strongly on plant based foods. You should read from our own wiki
Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs)
https://wiki.apoe4.info/wiki/Gut-Brain_C ... _(gut_bugs)
There are also anti-inflammatory, adaptogenic (stress lowering), mitochondrial, vasodilation, oxygenation, antioxident, amyloid clearance, and more, benefits. Admittedly, just because it's a plant doesn't mean it's beneficial, I've had to eliminate certain plant foods (lectins) to reduce my inflammatory markers. But many plants offer superfood benefits.
Also remember as ApoE4s, we're the ancestral gene. It was only 400,000 years ago that man started to hunt large game on a regular basis. Before that humans were foragers and scavengers subsisting mainly on gathering plants, insects, small animals. Early humans ate a varied, plant-based diet, that's the diet our gene yearns for.
Here's just A FEW references on plant food/derivative substances and their benefits:
Neuroprotective Herbs for the Management of Alzheimer’s Disease
https://www.mdpi.com/2218-273X/11/4/543 ... xyT1N1TTE#
Adding a blend of spices to a meal may help lower inflammation
http://www.sciencedaily.comireleases/20 ... 115627.htm
Root bacterium to fight Alzheimer's
http://www.sciencedaily.com/releases/20 ... 120039.htm
Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease
https://www.frontiersin.org/articles/10 ... 19024/full
Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions
https://www.frontiersin.org/articles/10 ... 04462/full
The protective effects of polyphenols on Alzheimer's disease: A systematic review
https://alz-journals.onlinelibrary.wile ... 018.09.002
Dietary Polyphenols, Mediterranean Diet, Prediabetes, and Type 2 Diabetes: A Narrative Review of the Evidence
https://www.hindawi.com/journals/omcl/2017/6723931/
Phytochemicals and cognitive health: Are flavonoids doing the trick?
https://www.sciencedirect.com/science/a ... via%3Dihub
Health benefits of olives and olive oil
https://www.sciencedaily.com/releases/2 ... 161025.htm
Olive-Oil-Derived Oleocanthal Enhances β‑Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In Vitro and in Vivo Studies
https://pubs.acs.org/doi/10.1021/cn400024q
Neuroprotection with Natural Antioxidants and Nutraceuticals in the Context of Brain Cell Degeneration: The Epigenetic Connection
https://pubmed.ncbi.nlm.nih.gov/31789133/
Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway
https://www.sciencedirect.com/science/a ... via%3Dihub
Natural Products as Modulators of Sirtuins
https://www.mdpi.com/1420-3049/25/14/3287
More Flavonol, Less Alzheimer's
https://www.medpagetoday.com/neurology/ ... ease/84603
More berries, apples and tea may have protective benefits against Alzheimer's
https://www.sciencedaily.com/releases/2 ... 121701.htm
Medicinal Plants for Cardiovascular and Neurodegenerative Aging-Related Diseases: From Bench to Bedside
https://www.frontiersin.org/articles/10 ... 85155/full
Long-term dietary flavonoid intake and risk of Alzheimer disease and related dementias in the Framingham Offspring Cohort
https://academic.oup.com/ajcn/article/112/2/343/5823790
Is Cocoa Good for the Brain?
https://www.news-medical.net/health/Is- ... Brain.aspx
Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults
https://www.nature.com/articles/s41598-020-76160-9
The Effects of Flavonoids in Cardiovascular Diseases
https://www.mdpi.com/1420-3049/25/18/4320
Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?
https://www.mdpi.com/1420-3049/25/13/3060
Molecular Level Insight Into the Benefit of Myricetin and Dihydromyricetin Uptake in Patients With Alzheimer’s Diseases
https://www.frontiersin.org/articles/10 ... 01603/full
Nootropics, Functional Foods, and Dietary Patterns for Prevention of Cognitive Decline
https://www.sciencedirect.com/science/a ... 3768000198
Dietary flavonols and risk of Alzheimer dementia
https://n.neurology.org/content/94/16/e1749
Cocoa flavanols boost brain oxygenation, cognition in healthy adults
https://www.sciencedaily.com/releases/2 ... 092154.htm
Citrus Polyphenols in Brain Health and Disease: Current Perspectives
https://www.frontiersin.org/articles/10 ... 40648/full
Interaction of Cinnamaldehyde and Epicatechin with Tau: Implications of Beneficial Effects in Modulating Alzheimer's Disease Pathogenesis
https://content.iospress.com/articles/j ... /jad122113
Cinnamic Acid Derivatives and Their Biological Efficacy
https://www.mdpi.com/1422-0067/21/16/5712
Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies
https://www.mdpi.com/2072-6643/13/2/537
The Benefits Of Broccoli Sprouts In TBI And Other Neurodegenerative Conditions
https://www.prohealth.com/library/benef ... ions-89704
Antioxidant Activity of Polyphenolic Plant Extracts
https://www.mdpi.com/2076-3921/9/1/19