interesting question, J11. I've been thoughtfully pondering it ever since you've posed it. The younger me would have eagerly jumped at the chance to have a "perfect" baby, but almost 53 y/o me wouldn't trade my imperfect 3/4 baby for all the tea in China- spoken like a true Mommy. Nor would I have wanted my parents to have denied me the opportunity for life.
Understanding that the E4 allele is the original ancestral allele, I can't help but wonder if it confers some evolutionary advantage that we may not yet be aware of
Among those of us living a Westernized lifestyle, I tend think that the only disadvantage we experience is that of a genetic/environmental mismatch. Rather than tinkering with the original APOE gene...shouldn't we instead be focusing on cleaning up our lifestyle? Thinking big picture; isn't our mismatch a good analogy for what we've done to the planet? Perhaps cleaning up that and our food supply, etc. might be a better path. Tinkering with evolution is a lot like playing with fire; could turn out OK, could be a disaster.
I DO like your Alzheimer's network diagrams, especially the second more expanded one. It beautifully demonstrates the myriad opportunities we have for working on optimal health to avoid this devastating disease. It also strongly supports a systems approach to preventing/treating the disease, like Dr. Bredesen is applying.
Lance, ANOTHER amazing thought-provoking post.
E4s seem to be different and to the point of many recent posts, some of us E4s respond in dramatically different ways to external, internal etc stimuli. Figuring all that out is becoming possible, but given our state of the "patient-doctor" relationship, I see no way this can be effectively scaled and implemented.
Agreed, with our current system; but did you see my recent post on P4 medicine? THAT gives me much hope. Dr. Hood has been approached by seven different countries, who are exploring implementation. He has backing from major philanthropists like Bill Gates, etc. It's happening, my friend...perhaps sooner than you'd think.