I finally had an opportunity to read the full study (with tables!) thanks to Bulldog Stavia
Because the cholesterol hypothesis is so pervasive, I always like to go back to raw data to see if my interpretation jives with the study conclusions and in this case with Dr. Michael Greger's interpretation that even "moderately elevated cholesterol increases dementia risk."
Using the demographic data from Table 1, it looks like Greger partially
got it right. The modifiable risk factors that predisposed a participant to having neuritic plaques (NPs) are presented below in order of their significance.
-Fasting Insulin, 22.23%
-LDLC, Non-HDLC, TGs- 20%
-Blood Glucose, 5%
to focus on cholesterol, but it turns out (just using the data from this study) that the LDLC/HDLC and TC/HDLC ratios are MUCH bigger drivers of neuritic plaque that LDLC or TC alone. LDLC is in 5th place at 20% and TC is in 6th place at 10%.
What really caused my head to head to spin, was learning those with
NPs lived on average seven years longer. And, higher systolic and diastolic BP as well as cigarette smoking protected against NPs. Huh?
I think we should get right down to business and figure out how us ~4's can reduce APOB but thats another thread.
Agreed, Hep! PLEASE start a thread on how to reduce LDLC/APOB, but let's make reducing cholesterol ratios
& fasting insulin while increasing exercise an even bigger focus.