Just want to say this may be one of the wisest summaries I've seen yet….
Fully agree there is a lipid conundrum, but I also think that once we 'get it', it will be simple. Although an outlier, and focussed on heart disease, this may be a good place to remind that the contrarian view of Dr Gundry (whose basis is clinical experience) is that it is indeed size, not number, that matters.Juliegee wrote:I'm a sad substitute for sweet Max (waves ) but I thought I'd chime in with my notes from Dr. Isaacson's talk at our recent conference.
He liked Dr. Martha Clare Morris’s MIND Diet with a few modifications for E4s. IMO, many of us are already eating much healthier, but this is a good way to transition from SAD: https://www.rush.edu/news/press-release ... rs-disease
-MORE exercise for E4s
-ONLY organic produce for E4s
-Omega 6:3 ratio should be 2:1 for E4s. More fish for E4s than what MIND recommends. (EDIT: When I spoke with him in NYC, Max did report taking fish oil per Dr. Isaacson's direction.)
-Less SFA for E4s (Martha heard 7% of total diet)
-1/3 less whole grain than MIND for E4s.
-PM Carb restriction: starting with 12 hours, then 14, finally 16 hours
-Higher protein 25% of diet (?)
-E4s must play a musical instrument. Dr. Isaacson is in a rock band called The Regenerates as opposed to degenerates
He mentioned Dr. Gary Gibson’s paper below was hugely influential. (I still haven’t read it.)
A Mitocentric View of Alzheimer’s Disease Suggests Multi-Faceted Treatments
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085842/
By way of three case studies he collaboratively shared with the group, he reported wanting to experiment with MCT/ketosis- especially on his E4 patients, but he was stymied by the high lipids. Like Dayspring, he likes lipid numbers to be in range and is currently prescribing statins for his patients. He’s very tuned in to their potential negative effects- especially on E4s. He (and all of the experts there) are stuck on this conundrum: how to use ketosis safely in our population?
What am I forgetting, Martha?
Beyond that, I want to underscore the connection between 'organic' and 'grain' bullets (not that common)… and add, that I'm willing to bet if you do eat grains, preparation matters - i.e. natural fermentation like real sourdough may even be more important for us (to avoid inflammatory response).