On the other hand, her message is MUCH more geared towards folks who are using a ketogenic diet because it's cool or trendy rather than to address neuro-degeneration. These are the same folks who might be applying it in an unsafe way with very limited carbs and high SFA without a physician's oversight and regularly checking effects/biomarkers.
Anyone who KNOWS our community can easily recognize that those of us who use this strategy practice it very differently by concurrently employing CR, fasting, and exercise to safely create ketones. Most of us eat enormous quantities of non-starchy vegetables and use MUFAs to stay heart healthy. Additionally, we're interacting with top cardiologists and lipidologists in an effort to keep our members heart healthy.
Do you have a reason to believe CR, fasting and exercise are safer than a high-fat, low carb, low protein diet? I'm not aware of any data that shows one approach to be safer than another.
Most of the long-term ketogenic diet research has been conducted with epilepsy, predominantly in children. By long-term, I mean rarely more than a year or two. What may feel like a miracle cure for cognitive problems in the short term by no means ensures ongoing benefit or lack of adverse effects over the long term. If we are looking to a ketogenic diet to prevent dementia, we are clearly in uncharted territory. Just because some are using diet rather than a drug, it does not mean they are inherently safer in this case.
Juliegee wrote:I was most intrigued by her assertion that a ketogenic diet suppresses the innate immune system, while stimulating the adaptive. Ballantyne suggests this is positive when fighting cancer, but may not be for other conditions. Research shows that E4 carriers experience impaired immunity which may play a role in the development of Alzheimer's. I want to learn more about how a ketogenic diet mechanistically interacts here.
GeorgeN wrote:For me, I've cycled in and out of mild ketosis - 0.5 - 1.5 mmol/L and remained "keto adapted" for about 4.5 years. The ability to tap keto fuel at will has been very useful.
Leptin The most reliable test for monitoring leptin levels is the radioimmunoassay (RIA), which utilizes an antibody that responds to leptin in a fasting blood sample. This test will tell you whether or not you have leptin resistance. If your level is in a healthy range— the optimal fasting leptin level is between 4 and 6 ng/ dL and up to 9 ng/ dL is acceptable— your cells are sensitive to leptin’s signals. You are a fat burner as nature intended you to be, and it is unlikely that you will have a weight problem. (If you lower your leptin levels to optimal levels, as you most certainly will on the Rosedale Diet, it is highly unlikely that you will continue to have a weight problem even if you started out with one.) Of course, we don’t want leptin levels to go too low. Anything below –4 ng/ dL is a sign of either malnutrition, usually accompanied by very low body fat, or a genetic inability to produce leptin that results in obesity. (If a woman’s leptin level falls below 3, generally caused by very low stores of body fat due to inadequate food intake or intensive exercise, she will stop menstruating.) If your fasting leptin level is 10 ng/ dL or higher, you will most certainly benefit from the leptin-sensitizing program outlined in this book. Most obese people have extremely elevated leptin levels: 20, 30, even 40 ng/ dL! Yet within only two to three weeks on the Rosedale Diet, almost everyone experiences a dramatic decline in leptin levels. At the same time, they eat less because they do not feel hungry as often as they used to. They no longer experience food cravings and have little difficulty following the diet. If your leptin level doesn’t fall as quickly as it should (younger people often have quicker results than older people), you need to be especially careful about following the diet and perhaps add extra nutritional supplements. But if you follow the program, I promise that your leptin sensitivity will improve and your fasting leptin level will fall. Leptin: 4 to 6 ng/ dL optimal; up to 9 ng/ dL acceptable; 10 + ng/ dL high.
Rosedale M.D., Ron; Carol Colman (2009-10-13). The Rosedale Diet (pp. 166-167). HarperCollins. Kindle Edition.
When sharing cautions, I think it’s important to discuss degrees of ketosis. Dr. Cunnane, for instance, has recommended that as little as .3-.5 mmol/L of beta-hydroxybutyrate for E4 carriers may be able to preventatively offset our cerebral glucose hypometabolism. I’m guessing that low of a level would naturally occur during sleep in someone not restricting carbs. Of course, those already experiencing cognitive symptoms would need higher levels. FWIW, as someone who HAS experienced cognitive decline, I personally aim for mild ketosis (.7-1.5mmol/L,) mild CR, a 12-16 hour daily fast, and exercise. The combination has greatly improved my cognition for over two years. Aside from some muscle loss (working on it ) I've escaped any detrimental consequences so far...
ApropoE4 wrote:The trouble with long term ketogenic diets is that we don't know if the risk increases they exhibit in children for kidney stones and bone fractures are additive or multiplicative. That is, if children put on this diet for years end up developing kidney stones ten times more frequently than their peers, nobody can say if it's just that we see an additional 20 cases per 1000 and the same would be true for middle aged folks, or if all of you keto-addicts are going to be getting kidney stone surgery instead of ultrasound treatment because your bones become to brittle to withstand the latter. I
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