LOL, Stavia- I don't think we even have a site quotation anymore. We may have lost it in our latest upgrade. But, I like "Knowledge is Power" as well. We'll have to search for a new spot.
Richard, I listened to Sarah Ballantyne's talk- 79 mins long. For anyone short on time, you can easily skip the first 30 mins where Ballantyne basically discusses how she FEELS
about the topic...without missing any of the content. The remaining talk was informative. This was essentially a preview of a Paleo f(x) talk that goes down tomorrow warning of the dangers of ketosis. I appreciated Ballantyne's intense combing of the literature to find adverse effects...and she did, including death
I certainly want to know everything that I can about any strategy that I'm employing.
I was most intrigued by her assertion that a ketogenic diet suppresses the innate immune system, while stimulating the adaptive. Ballantyne suggests this is positive when fighting cancer, but may not be for other conditions. Research shows that E4 carriers experience impaired immunity which may play a role in the development of Alzheimer's. I want to learn more about how a ketogenic diet mechanistically interacts here.
On the other hand, her message is MUCH more geared towards folks who are using a ketogenic diet because it's cool
rather than to address neuro-degeneration. These are the same folks who might be applying it in an unsafe way with very limited carbs and high SFA without a physician's oversight and regularly checking effects/biomarkers.
Anyone who KNOWS our community can easily recognize that those of us who use this strategy practice it very
differently by concurrently employing CR, fasting, and exercise to safely create ketones. Most of us eat enormous quantities of non-starchy vegetables and use MUFAs to stay heart healthy. Additionally, we're interacting with top cardiologists and lipidologists in an effort to keep our members heart healthy.
Dr. Yadong Huang, and others, suggest that our misshapen E4 protein may lead to an impaired mitochondrial function. Indeed, we have a strong body of research (Eric Reiman, Richard Caselli, etc.) demonstrating that E4 carriers, in a dose dependent manner, experience reduced cerebral glucose metabolism per PET/FDG imaging beginning decades before the onset of symptoms. Because our brains are the most metabolically demanding organ, it makes sense that the deficiency would show up there first. At the recent NYC conference, there seemed to be a convergence of scientists acknowledging that this mitochondrial deficiency/cerebral hypometabolism occurs years upstream of amyloid and tau deposition. Dr. Stephen Cunnane’s work has suggested that even mild ketones can help address this deficiency in a high risk population like ours, but it's never been trialed preventatively in a research setting; much less been PROVEN to be effective.
For some of us, already experiencing cognitive symptoms, we don't have time to wait for the Cochrane Report. We're doing the best we can for now. I agree with Ski, Merouleau & Stavia. Until science can catch up, N=1 rules.