Oh, and I meant to tell y'all something about exercise and female e4s. It's probably gonna be a stretch, but bear with me:
When I was in my mid-20s (I want to say 25?) and living in NYC, I started having horrible PMS and extremely painful secondary dysmenorrhea. Guess it was karmic payback for my poo-pooing all my high school girlfriends who complained about cramps in their teens...I never experienced them...until I hit my mid-20s.
Okay, so in addition to the painful cramps, I would blow up like the Michelin/Stay Puft Marshmallow man. It wasn't unusual at all for me to gain 8-15 lbs. in water weight one-two weeks before my menses. And I was thin-normal in my 20s and fairly fit. This was the dawn of Jane Fonda's aerobic tapes and I was a practitioner of same. Not consistently, but I would do them.
This was also at the start of the whole PMS thing, so I started reading all the books I could find (even then, I was a PITA with the medical learning). There was one gyny who was the tippy-top PMS expert - he wrote one of the landmark books on PMS - damned if I can recall his name. AND his practice just happened to be in NYC. Yay!
So I made an appointment. Got some labs drawn. Did a followup. At the followup, he spent a lot of time with me and asked if I exercised. I said yeah, sporadically, but I do. I'll never forget this - and this was before ApoE hubbub was somewhat mainstream - he very seriously told me: "Lillianne, you must, must, must exercise aerobically most of the time all of your life and never ease up. Your specific biology needs it just to be normal. I cannot emphasize this enough. You need it just to be normal."
So. Did I fit a profile? Was my whacked-out PMS body a female 4/4 body even then? Dunno. But it's kinda eerie to me...