Juliegee wrote:Just found this new paper examining the relationship between fish oil, LDL-C and LDL-P. Despite the anecdotal evidence shared here, no deleterious relationship between fish oil and APOE genotype was found.
http://link.springer.com/article/10.100 ... 014-9554-8
Strengths and Limitations
Strengths of the study include a very large sample size, the use of an objective biomarker sensitive to changes in omega-3 fatty acid intake (the Omega-3 Index), and a broad spectrum of unselected patients with an APOE genotype distribution similar to that in other cohorts. There were also limitations; this was not a randomized trial of fish oil supplementation in patients with different APOE genotypes but a retrospective, medical records-based analysis. As such, we had no data on comorbidities or lifestyle factors for these patients. Perhaps more importantly, we had no information on concomitant drugs, and it is possible that pharmacologic regimens differed by genotype. This could confound the relations observed here and limit the conclusions that could be drawn from them.
Gilgamesh wrote:I chomp a little EPA and DHA, but I try to emphasize high quantities of plant-based omega-3s. (That, by the way, is what the references in Lara P.'s famous article support, even if the article itself says something diff.)
Jack Norris wrote:If it weren't for the (small chance) for potential eye problems, I would suggest either adding 3 g of ALA per day or taking DHA supplements. Because of the eye issues, that much ALA is not worth the risk when DHA supplements are available. I would still recommend adding about .5 g of ALA per day for its own benefits for heart disease and to help increase EPA levels. If using such small amounts of uncooked, plant sources of ALA the risk to the eyes should be minimal.
Jack Norris wrote:Add 0.5 g of uncooked ALA to your diet daily (see chart). This would be the equivalent of:
1/5 oz English* walnuts (3 halves)
1/4 tsp of flaxseed oil
1 tsp of canola oil
1 tsp ground flaxseeds
The studies finding ALA to be linked with eye problems were all done on only one population by one group of researchers, measuring intakes rather than blood levels. I consider it likely that further studies will show inconsistencies and until plant and/or uncooked sources of ALA are examined, I am skeptical that uncooked, plant sources of ALA are harmful to the eye.
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