Thanks for re-posting the Pizzorno paper, Spunky. It's posted elsewhere on the site, but not on this thread
Merouleau, I hear you, my friend. That certainly gives the appearance
of impropriety... But, many of these scientists and physicians do the same from the Deepak/Chopra team to Perlmutter. The fact that Peskin sells supplements IS suspect, but I'm still trying to hear the message.
I, too, wish those, who agree with Peskin; would chime in here. Read the thread from the beginning. Others argue his position eloquently.
The scientists with http://www.CognitiveVitality.org
team reviewed all of the data & concluded that YES, fish oil is likely to be neuro-protective; NOT for E4s.
Sigh. So, what are we 4/4s to do? Strategy, after strategy (with the exception of physical exercise!!!) is beneficial to non-E4 carriers, but not for us.
I'm just speaking for myself here, but I'm reading all that I can to understand how ApoE4 alters lipid homeostasis and increases oxidative stress and trying to incorporate that
with my understanding of how fish oil provides neuro-cognitive protection. I'm hoping that by maintaining a diet rich in both plant & animal N-3s (along with 900 mg DHA) chock-full of dietary (and supplemental) antioxidants, I MAY be able to derive the same benefit as non E-4 carriers. I'm guessing the previous E4 studies didn't include folks like you and I- eating so pristinely to overcome the ApoE4 obstacles.
E4 Mice, eating their version of Souvenaid (combo of N-3 & antioxidants), DO show benefit. I have to review the literature, but I think a few
E4 folks using Souvenaid as well. Then there's lipidologist Thomas Dayspring, upon being asked dietary advice for ∈4s, on a podcast with Jimmy Moore. He suggested that a ketogenic diet might ward off Alzheimer’s. He then goes on to recommend
Drown yourself in omega-3 fatty acids” if you carry an ∈4
Definitive evidence for protection from N-3s is lacking for our population, but it doesn't mean we can't try
I've gone back and forth on this... and probably will again. In the meantime, let's stay on top of the most current research so we can chose educated strategies for ourselves.