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Melatonin

Alzheimer's, cardiovascular, and other chronic diseases; biomarkers, lifestyle, supplements, drugs, and health care.
circular
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Re: Melatonin

Postby circular » Mon Jun 22, 2015 6:40 pm

I'm only done with the first page of this thread, but before I forget my thought, in response to the early posts in it being wary of supplementing hormones vs vitamins, just a reminder that "vit D" is a hormone and we're encouraged to take pretty high doses because of its importance. Not that it's apples to apples with melatonin, but a sort of precedent for hormone supplementation sometimes being critical. I'm leaning toward taking 2 mg time release as used in the second study below, but I plan on testing it if there's a test. i also tend to have sleep and circadian issues (thankfully improving). If I'd never had sleep issues I might think twice.

"Melatonin is selectively taken up by mitochondrial membranes, a function not shared by other antioxidants" http://www.ncbi.nlm.nih.gov/pubmed/26087000

"Differences were more significant at longer treatment duration. PRM [2 mg prolonged release melatonin] was well tolerated, with an adverse event profile similar to that of placebo. Conclusion: Add-on PRM has positive effects on cognitive functioning and sleep maintenance in AD patients compared with placebo, particularly in those with insomnia comorbidity. The results suggest a possible causal link between poor sleep and cognitive decline."
http://www.dovepress.com/add-on-prolong ... rticle-CIA
ApoE 3/4 > Thanks in advance for any responses made to my posts.

GenePoole0304
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Re: Melatonin

Postby GenePoole0304 » Mon Jun 22, 2015 7:34 pm

added to post
there is another article I recently posted somewhere suggesting 2mg time release worked to improve cognitive function in Alz somehow missed or I forgot to post it!.
this is similar
http://www.ncbi.nlm.nih.gov/pubmed/24971004
http://www.prnewswire.com/news-releases ... 03871.html


the thing about melatonin is it can shift ones circadian rhythm so it is important to time its use with a normal cycle. Supplementing too late or early at night causes the shift. One should get used to going to bed earlier so one can sleep 8-9 hours to wake up to morning sunrise. The rhythm then is used to time other body functions so there is a concern.
I sometime use 300mcg or 3mg time release.

hormone supplementation is ok if one is low but the problem is that few doctors understand how to achieve balanced hormones. See lef.org for guidelines. One can raise ones levels naturally only so far.
I though I had a problem when they were too high but there is no real upper limit and it was like this two years running!

circular
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Re: Melatonin

Postby circular » Mon Jun 22, 2015 10:14 pm

I'm starting to think it would be interesting to really adjust my sleep schedule for a year according to the sun, rather than consistent 10-6. This time of year where I live I'd be going to bed at 8:30 or so, but it would help me get that early morning sunlight which is supposed to be the best for circadian rhythms and otherwise, though I've not seen or looked for studies on that in particular.

I'm also thinking about:

"Melatonin is selectively taken up by mitochondrial membranes, a function not shared by other antioxidants" http://www.ncbi.nlm.nih.gov/pubmed/26087000

Why would that be? There must be a reason that it gets into the mitochondria where other antioxidants don't, and it must occur in circadian waves, so perhaps it has to do with energy regulation shifts during the circadian phases. And there must be a cell mitochondria barrier, just like a blood brain barrier and gut blood barrier, and maybe that gets leaky too! :shock: I hope I get the credit when that concept goes down in history, 'cause you know no one else has ever thought of that! ;)
ApoE 3/4 > Thanks in advance for any responses made to my posts.

GenePoole0304
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Re: Melatonin

Postby GenePoole0304 » Wed Jun 24, 2015 2:52 pm

remember one time I took it at 900pm and then had a call into work! it was hard to keep my eyes open driving.

http://www.marksdailyapple.com/melatoni ... for-women/


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