tramiprosate

[aphorist]

ALZ drug specifically targets APOE-4 population. Best results seen in homozygous E4 subjects. Phase I successfully completed.

http://www.bizjournals.com/boston/blog/ ... l?page=all

PLEASE POST FURTHER DISCUSSION ITEMS RELATED TO THIS DRUG IN THREAD.

[Silverlining]

More relevant and potentially exciting developments for us and our "4" family members. Thanks for digging this out of Biogen's shadow

[ApropoE4]

This is of course a compound with dodgy history. Having failed to show improvement in the clinical trials, the company that was developing it then tried to get the FDA to agree that it's not a drug at all, but a naturally occurring amino acid. When that didn't take, they switched to marketing it in Canada, where regulation is not as strict. Now, if we believe them, they've figured out some of the reasons why they failed the test (too low half-life, no apoe4 testing) and have made some improvements to the delivery mechanism that will make it effective. Whether that's true or they're just panicking over the Biogen announcement... we'll see.

http://www.alzheon.com/?page_id=280

[Julie G]

Thanks, Aphorist. The fact that is shows improvement in both brain pathology AND cognition specifically in E4 homozygotes is noteworthy. I'm cautiously optimistic.

[J11]

The company developing it is not the same company that ran the phase 3s.

The new company saw the promise that has already been reported for the phase 3 results and reformulated it.
The line up for the France meeting has probably been known for months.