Thanks circular
I don't see CYPR21 in my PROMETHEASE report? So will have Vitamin D tested for.
Thanks for the great reference paper on "nutrigenomics".
After reading, I went back to take a closer look at my PROMETHEASE report (I think I was in E3/E4 shock and didn't pay attention to anything else!) and saw this finding:
MTHFR rs1801133 (T;T) Bad 3.0
- homozygous for C677T of MTHFR = 10-20% efficiency in processing folic acid = high homocysteine, low B12 and folate levels
So looks like my folate/MTHFR are "possibly" bad, need to most certainly check my homocysteine level.
I've already started B12 supplement, and she recommends two other B vitamins (folic acid and B6), also confirmed in this paper re high levels homocysteine and AD:
http://www.ncbi.nlm.nih.gov/pubmed/23690582
Quoting the abstract:
In an initial, randomized controlled study on elderly subjects with increased dementia risk (mild cognitive impairment according to 2004 Petersen criteria), we showed that high-dose B-vitamin treatment (folic acid 0.8 mg, vitamin B6 20 mg, vitamin B12 0.5 mg) slowed shrinkage of the whole brain volume over 2 y. Here, we go further by demonstrating that B-vitamin treatment reduces, by as much as seven fold, the cerebral atrophy in those gray matter (GM) regions specifically vulnerable to the AD process, including the medial temporal lobe. In the placebo group, higher homocysteine levels at baseline are associated with faster GM atrophy, but this deleterious effect is largely prevented by B-vitamin treatment. We additionally show that the beneficial effect of B vitamins is confined to participants with high homocysteine (above the median, 11 µmol/L).
Is their high conviction/taking of this B vitamin regiment in this forum?
I also read her APOE4 paper reference, very informative:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001305/