Thanks for the great community...I can't thank you enough for creating such a valuable resource! Since I'm new here, I'd like to take a moment to introduce myself. I'm a 63 year old, female, ApoE3/4, retired Clinical Research Specialist/MBA with no known health issues and no family history of Alzheimer's. I have an 85 year old very active Mother who is also an ApoE3/4 and cognitively intact.
As a side note, after DNA testing through 23andme, I interpreted our raw data and determined our ApoE status. When I started analyzing our raw data, I had a heart-to-heart with my Mother and asked her if she wanted me to tell her "the good with the bad" and she said "yes". After I told her about our ApoE status she asked me, "is it guaranteed that I'll get AD", and I told her that it is a risk factor and that very few genes are fully penetrant. She told me she's not going to worry about it then.
With our similar, yet often divergent, genetics, I think my Mother and I would be an interesting N=2. Here are a few snps for comparison. For the CETP gene snp, I have rs5882 AG (TC 157, TG 56, HDL 58, LDL 91) and my Mother has rs5882 AA (TC 240, HDL 55). We are both AA for the TOMM40 gene snp rs2075650 and are in the K1A1 haplogroup. We do not have the C677T gene mutation; and are both at increased risk for celiac disease per 23andme, but have never had any issues.
I've tried to maintain a healthy BMI, active lifestyle, and low-glycemic diet eating real food -- kefir, grass fed butter, EVOO, organic pastured eggs, nuts, dark chocolate, beans, sprouted bread or whole grains, fruits, veggies, hormone free/antibiotic free meats and poultry. I also try to "fast" for 12 hours every day and make sleep [in a black out environment] a priority. In all honesty, I do have an occasional beer or glass of wine, piece of pizza -- thin crust of course, or sweet treat. My avoid list includes high fructose corn syrup, artificial sweeteners, processed vegetable oils, trans fats, fried foods, nitrates/nitrites, processed foods, artificial colorings/dyes, or anything else I can't pronounce.
I'm an enthusiastic fan of Dr. Chris Masterjohn, and have been following his work on Vitamin K2 for a few years. Ever since he mentioned that he carries one ApoE4 allele in a podcast, I've considered him a kindred spirit. Inspired by the plethora of information in this community, I'm creating a "must read" list now from the forums here. Many, many thanks for the fantastic learning environment. Kudos to everyone...I can't thank everyone enough for all of their dedication and hard work!