Help with APOE snps

Newcomer introductions, personal anecdotes, caregiver issues, lab results, and n=1 experimentation.
Alrklein
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Help with APOE snps

Postby Alrklein » Wed Sep 19, 2018 1:23 am

Hello, i have been concerned about cognitive decline for a couple of months now, and went back to 23andme and they seem to have a new Alzheiners report which shows me at slightly grater risk.

In terms of e3/e4 etc i cant seem to inrepret my data

The 2 heterozygous snps i have are :

Rs429358 CT +-

Rs769449 AG +-

Can anyone interpret?

Thank you

Matisse
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Re: Help with APOE snps

Postby Matisse » Wed Sep 19, 2018 5:48 pm

Please also provide results for RS7412 to determine full apoe status.

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Re: Help with APOE snps

Postby slacker » Wed Sep 19, 2018 6:11 pm

Alrklein wrote:Hello, i have been concerned about cognitive decline for a couple of months now, and went back to 23andme and they seem to have a new Alzheiners report which shows me at slightly grater risk.




Hi Alrklein;

23&me gives its clients raw data, which needs to be converted into easier to interpret results. This can be done with a variety of tools such as Promethease. You can find out more about Promethease by doing a search (magnifying glass in tool bar right upper corner of website) on "promethease", but you'll ultimately need to go to their website to get the job done.

Good luck, and welcome!
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E4/E4

Alrklein
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Re: Help with APOE snps

Postby Alrklein » Thu Sep 20, 2018 12:55 am

Matisse wrote:Please also provide results for RS7412 to determine full apoe status.

All others are —

RS7412 is CC thanks

I will look at promethease

Many thanks

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Chameleon
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Re: Help with APOE snps

Postby Chameleon » Thu Sep 20, 2018 8:49 am

Welcome Alrklein to the APOE4 website. Kudos to you for getting the test done and getting them Interpreted.

If you are comfortable, let us know what your experience was with Promethease and how it turned out for you.

You may also want to check out the Primer that Stavia wrote, which contains wonderful information.
Please feel free to continue asking questions and sharing your journey.

We look forward to hearing more from you!

Matisse
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Re: Help with APOE snps

Postby Matisse » Thu Sep 20, 2018 10:13 am

You are apoe 3/4. Promethease will confirm it as well as give lots more info.


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