Hello
My last bit of blood work showed my active B12 to be quite high and outside the normal range.
I stopped supplementing with b12, but am now wondering whether I should have — especially given the importantance Bredesen puts on the vitamin. Perhaps being outside the normal range is a good thing?
Any wisdom would be gratefully received.
Should I stop supplementing with b12?
Should I stop supplementing with b12?
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Re: Should I stop supplementing with b12?
Cognitive decline is associated with low "normal" B12. You can read more here. Dr. Bredesen's recommended levels are optimized to be neuroprotective.
Re: Should I stop supplementing with b12?
Alexis;
US units for Vit B12 are in pg/mL. A conversion program I found showed 218 pmol/L is equivalent to 295.32 pg/mL. One national US lab company (Lapcorp) has a "normal" range of 232 - 1245 pg/mL. This is very different from the normal range shown in your attachment.
Would someone else check my "math"?
US units for Vit B12 are in pg/mL. A conversion program I found showed 218 pmol/L is equivalent to 295.32 pg/mL. One national US lab company (Lapcorp) has a "normal" range of 232 - 1245 pg/mL. This is very different from the normal range shown in your attachment.
Would someone else check my "math"?
Slacker
E4/E4
E4/E4
Re: Should I stop supplementing with b12?
FWTW fact sheet - https://ods.od.nih.gov/factsheets/Vitam ... fessional/Alexis wrote:My last bit of blood work showed my active B12 to be quite high .,, Any wisdom would be gratefully received.
Re: Should I stop supplementing with b12?
Hi Alexis,Alexis wrote:Hello
My last bit of blood work showed my active B12 to be quite high and outside the normal range.
I noticed that you mentioned the NHS on a previous post, so thought I'd check with what UK recommended levels are currently. This is from 2018 guidance in Hull and Yorkshire, but does suggest what Slacker said: that you lab chart seems off, not your current level.
Guidelines for the Investigation and Management of Vitamin B12 and Folate DeficiencyThe normal ranges for B12 and folate levels based on the above methodology are:B12 (115 to 1000 pmol/L) (B12 levels just within the normal range can lead to symptoms so results 115-150 should be assessed on an individual basis)
4/4 and still an optimist!
Re: Should I stop supplementing with b12?
I just returned from an appt with Mitsu, Dr Gundry's PA. My blood levels for B12 (taking 1000 mcg daily) is 1376 pg/ml by Veridia labs which is at the top for normal on Veridia's standards. Mitsu increased my intake to 5000 mcg's daily. Seemed high considering. And yes I am heterozygous genotype for MTHFR C677T and A1298C and 4/4. She also Doubled my intake of TMG to 1000 mg's daily but left folate at 1000 mcg daily.
This was my initial appt with Gundry's office. I will follow up this visit in 6 months and see Dr Gundry in August.
This was my initial appt with Gundry's office. I will follow up this visit in 6 months and see Dr Gundry in August.
Re: Should I stop supplementing with b12?
Did you stop taking B12 supplements 2-3 days before your lab test?
B12 will circulate in your body before your body gets rid of it. Keep taking B12 (except before a test) as there are no drawbacks, only advantages. Your body will naturally get rid of what you don't use.
B12 will circulate in your body before your body gets rid of it. Keep taking B12 (except before a test) as there are no drawbacks, only advantages. Your body will naturally get rid of what you don't use.
e3/4 MTHFR C677T/A1298C COMT V158M++ COMT H62H++ MTRR A66G ++ HLA DR
Re: Should I stop supplementing with b12?
Thanks!slacker wrote:Alexis;
US units for Vit B12 are in pg/mL. A conversion program I found showed 218 pmol/L is equivalent to 295.32 pg/mL. One national US lab company (Lapcorp) has a "normal" range of 232 - 1245 pg/mL. This is very different from the normal range shown in your attachment.
Would someone else check my "math"?
I used a private company called Medichecks. It’s bizarre that what they stipulate as the normal b12 range should be so conservative — looks like I’ve got relatively low levels (at least in the US! )
Re: Should I stop supplementing with b12?
NF52 wrote:Hi Alexis,Alexis wrote:Hello
My last bit of blood work showed my active B12 to be quite high and outside the normal range.
I noticed that you mentioned the NHS on a previous post, so thought I'd check with what UK recommended levels are currently. This is from 2018 guidance in Hull and Yorkshire, but does suggest what Slacker said: that you lab chart seems off, not your current level.
Guidelines for the Investigation and Management of Vitamin B12 and Folate DeficiencyThe normal ranges for B12 and folate levels based on the above methodology are:B12 (115 to 1000 pmol/L) (B12 levels just within the normal range can lead to symptoms so results 115-150 should be assessed on an individual basis)
Thank you!
By the that metric, my levels are definitely not high. I think I’ll contact the lab test provider!
Re: Should I stop supplementing with b12?
Plumster, I did not stop B12. They did recommend I stop another vitamin which I wasn't taking at the time.