Genetic Mutation of ApoE protects against AD

Insights and discussion from the cutting edge with reference to journal articles and other research papers.
mike
Senior Contributor
Senior Contributor
Posts: 664
Joined: Fri Mar 09, 2018 4:55 pm
Location: CA - Sonoma County

Genetic Mutation of ApoE protects against AD

Postby mike » Mon Nov 04, 2019 12:07 pm

https://www.nytimes.com/2019/11/04/heal ... e=Homepage

The woman’s mutation is in an area of the APOE gene that binds with a sugar-protein compound called heparan sulfate proteoglycans (HSPG), which is involved in spreading tau in Alzheimer’s disease.


She has lots of AB plaque, but little Tau, and no signs of AD - could lead to drug treatment at some point.
Sonoma Mike
4/4

Fiver
Senior Contributor
Senior Contributor
Posts: 608
Joined: Wed Feb 01, 2017 12:51 pm

Re: Genetic Mutation of ApoE protects against AD

Postby Fiver » Mon Nov 04, 2019 5:13 pm

Saw this too. This seems like a really important clue!
Concerned, but hopeful. Introverted, but will talk about science.

User avatar
floramaria
Support Team
Support Team
Posts: 1005
Joined: Tue Jul 04, 2017 11:22 am
Location: Northern New Mexico

Re: Genetic Mutation of ApoE protects against AD

Postby floramaria » Mon Nov 04, 2019 7:18 pm

mike wrote:https://www.nytimes.com/2019/11/04/health/alzheimers-treatment-genetics.html?action=click&module=Top%20Stories&pgtype=Homepage

The woman’s mutation is in an area of the APOE gene that binds with a sugar-protein compound called heparan sulfate proteoglycans (HSPG), which is involved in spreading tau in Alzheimer’s disease.


She has lots of AB plaque, but little Tau, and no signs of AD - could lead to drug treatment at some point.

Very interesting. I just read the article in NY Times too. High accumulation of plaque with no cognitive problems. Lots of potential for progress In the area of treatment with this info on the benefits of having the Christchurch mutation.
Functional Medicine Certified Health Coach
IFM/ Bredesen Training in Reversing Cognitive Decline (March 2017)
Qualified ReCODE Practitioner

User avatar
thumperama
Senior Contributor
Senior Contributor
Posts: 168
Joined: Mon Aug 11, 2014 11:54 am

Re: Genetic Mutation of ApoE protects against AD

Postby thumperama » Tue Nov 05, 2019 9:22 am

I cannot read The NY Times article. Is there a source paper cited in it?

mike
Senior Contributor
Senior Contributor
Posts: 664
Joined: Fri Mar 09, 2018 4:55 pm
Location: CA - Sonoma County

Re: Genetic Mutation of ApoE protects against AD

Postby mike » Tue Nov 05, 2019 9:42 am

thumperama wrote:I cannot read The NY Times article. Is there a source paper cited in it?

Try this https://www.nature.com/articles/s41591-019-0611-3

She had LOTS of AB plaque, and yet no cognitive decline. This should put to rest that AB plaque is causing AD. Tau maybe.
Sonoma Mike
4/4

broiler_x
Senior Contributor
Senior Contributor
Posts: 49
Joined: Wed Aug 08, 2018 8:52 am

Re: Genetic Mutation of ApoE protects against AD

Postby broiler_x » Tue Nov 05, 2019 10:49 am

I saw this as well, very interesting finding. It was published in Nature Medicine which would indicate that the experts think this is very high impact research. This will be interesting to follow. And yes, another nail in the coffin of the amyloid hypothesis - how many nails does it take to seal a coffin, because this is like 20+?

broiler_x
Senior Contributor
Senior Contributor
Posts: 49
Joined: Wed Aug 08, 2018 8:52 am

Re: Genetic Mutation of ApoE protects against AD

Postby broiler_x » Tue Nov 05, 2019 10:50 am

Oh, and here's an article about this research that is accessible without a fee:

https://news.yahoo.com/why-didnt-she-al ... Redirect=1

Vikingman
Contributor
Contributor
Posts: 58
Joined: Mon Oct 14, 2019 1:17 am

Re: Genetic Mutation of ApoE protects against AD

Postby Vikingman » Tue Nov 05, 2019 1:02 pm

I ran across it earlier on this link.

https://www.sciencemag.org/news/2019/11 ... lzheimer-s

aphorist
Senior Contributor
Senior Contributor
Posts: 219
Joined: Sat Apr 19, 2014 3:47 am

Re: Genetic Mutation of ApoE protects against AD

Postby aphorist » Thu Nov 07, 2019 7:59 am



Return to “Science and Research”

Who is online

Users browsing this forum: No registered users and 16 guests