Hello everyone, I don't know if this has been posted before. I didn't see it when I checked.
https://www.nature.com/articles/s41467- ... 8/tables/2
From this recent study:
Really brought me down. I guess it's been a while since I read studies of the odds ratios and hazard risks. The authors point is that apoe2s have a really low incidence of AD. But the high risk for 4s seemed to jump off the page. I guess I'm a little stressed about things at the moment. Or maybe I'd just forgotten. But it is a good source of basic risk data, so here it is.
I was interested in the supplemental figures, but can't seen to access them. Maybe there is a broken link.
Published: 03 February 2020
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study
Eric M. Reiman, Joseph F. Arboleda-Velasquez, […]The Alzheimer’s Disease Genetics Consortium
Nature Communications volume 11, Article number: 667 (2020) Cite this article
Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer’s dementia, while the APOE2 allele is associated with a lower risk of Alzheimer’s dementia, it is not yet known whether APOE2 homozygotes have a particularly low risk. We generated Alzheimer’s dementia odds ratios and other findings in more than 5,000 clinically characterized and neuropathologically characterized Alzheimer’s dementia cases and controls. APOE2/2 was associated with a low Alzheimer’s dementia odds ratios compared to APOE2/3 and 3/3, and an exceptionally low odds ratio compared to APOE4/4, and the impact of APOE2 and APOE4 gene dose was significantly greater in the neuropathologically confirmed group than in more than 24,000 neuropathologically unconfirmed cases and controls. Finding and targeting the factors by which APOE and its variants influence Alzheimer’s disease could have a major impact on the understanding, treatment and prevention of the disease.