Associations Between Cardiovascular Risk, Structural Brain Changes, and Cognitive Decline

Insights and discussion from the cutting edge with reference to journal articles and other research papers.
Plumster
Contributor
Contributor
Posts: 446
Joined: Mon Oct 30, 2017 6:19 pm

Associations Between Cardiovascular Risk, Structural Brain Changes, and Cognitive Decline

Postby Plumster » Thu May 21, 2020 6:11 am

Here's a study from the Journal of the American College of Cardiology, concluding that
Higher cardiovascular risk burden may predict decline in episodic memory, working memory, and perceptual speed and is associated with neurodegeneration and vascular lesions in the brain.
They took apoe4 into account, too. I'd explore the results a little more, but my foggy CIRS brain is getting in the way. :(
Link to full paper
https://www.onlinejacc.org/content/75/20/2525
e3/4 MTHFR C677T/A1298C COMT V158M++ COMT H62H++ MTRR A66G ++ HLA DR

NF52
Support Team
Support Team
Posts: 1289
Joined: Tue Oct 25, 2016 9:41 am
Location: Eastern U.S.

Re: Associations Between Cardiovascular Risk, Structural Brain Changes, and Cognitive Decline

Postby NF52 » Thu May 21, 2020 3:20 pm

Plumster wrote:Here's a study from the Journal of the American College of Cardiology, concluding that
Higher cardiovascular risk burden may predict decline in episodic memory, working memory, and perceptual speed and is associated with neurodegeneration and vascular lesions in the brain.
...https://www.onlinejacc.org/content/75/20/2525
Here's a quote from the results section, that seems to suggest ApoE4 doesn't have the same impact from cardiovascular risk:
It is well known that APOE ε4 is a strong predictor of cognitive decline and dementia. Former studies have reported that the APOE ε4 allele was significantly associated with faster cognitive decline (4,13). In the current study, we found that the association between FGCRS and cognitive decline differed between APOE ε4 carriers and noncarriers. Specifically, the relationship between increased FGCRS [Framingham General Cardiovascular Risk Score]and faster cognitive decline was present mainly among APOE ε4 noncarriers. However, the interaction between FGCRS and APOE ε4 status on cognitive decline was not significant. There might be several explanations for this finding. First, the smaller sample size of APOE ε4 carriers may lead to a lack of power. Second, because APOE ε4 carriers are more likely to develop dementia, they might have been excluded at baseline.[emphasis added]

One chart in the article seems to suggest that ApoE4 might already have a baked-in effect: Over time the scores of study participants with ApoE 4 decline more than non-ApoE4 carriers on Global Cognition, Semantic Memory and Processing Speed when risk tertiles are combined. Middling good news: Changes in Episodic Memory, Working Memory and Visual Spatial Memory over time are no better and no worse between ApoE 4 and non-ApoE4 individuals.

If I'm reading this correctly, the title could have been "Individuals without ApoE 4 show association between cardiovascular risk and risk of dementia; people with ApoE4 must have something else going on".
4/4 and still an optimist!

Plumster
Contributor
Contributor
Posts: 446
Joined: Mon Oct 30, 2017 6:19 pm

Re: Associations Between Cardiovascular Risk, Structural Brain Changes, and Cognitive Decline

Postby Plumster » Thu May 21, 2020 4:14 pm

Haha! I like that.
e3/4 MTHFR C677T/A1298C COMT V158M++ COMT H62H++ MTRR A66G ++ HLA DR


Return to “Science and Research”

Who is online

Users browsing this forum: No registered users and 3 guests