2.14x increased risk for Alzheimer's
(hide) While the ApoE4 allele (rs429358(C)) is widely accepted as the predominant genetic risk factor for Alzheimer's disease, there are likely to be numerous other factors, both genetic and environmental, associated to lesser degrees with susceptibility to the disease. Genes influencing the immune system, and in particular susceptibility to viral infections such as herpes, may be among such factors. This SNP, located in the TAP2 gene and thus implicated in the activation of HIV and HSV-1 viruses, is seen more commonly in ~300 Alzheimer patients than in the same number of controls. The risk allele is rs241448(C). The odds ratio is reported to be 2.14 (CI: 1.02-2.55) for rsrs241448(C;C) homozygotes, and 1.51 (CI: 0.80-1.93) for rsrs241448(C;T) heterozygotes, compared with rsrs241448(T;T) homozygot..
Juliegee wrote:From the information you're shared, it looks like you're a heterozygote- one copy of the E4 allele. As a male, that only slightly increases your risk for Alzheimer's disease... but it's still good to have on your radar and practice prevention early.
Terrific record keeping, Cristoforo. Your results for lipids and glucose were good at your 4/7/13 test. Do you have any idea of what kind of diet you were eating in the weeks leading up to that test?
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