Here's what Greg wrote in his post from April titled Parasites & CIRS Update:
Apparently, HLA-DR testing has fallen out of favor. In 2017, Dr. Sonia Rapaport presented at the International Conference on Chronic Pathologies. At 10:30 in that presentation, she discusses the fact that the number of people that have a susceptible haplotype is much higher than the 24% reported by Dr. Shoemaker. Race, country, and ethnicity all play a role. For example, 90% of folks in Belgium have at least one “bad” halplotype. Given this, she seriously questioned the usefulness of HLA-DR testing.
Below [referring to a comment to Greg's post] Sean also points out that in the 2016 Irvine Mold Conference that Dr. Shoemaker himself commented that HLA-DR testing is questionable. I don’t have those videos, but I do have notes that others took of the conference. At that time, Dr. Rapaport was already looking into HLA-DR.
Personally, learning that I have two mold-susceptible haplotypes has been instrumental in my pursuit of the possibility that I have mold illness. The typical CIRS testing I had was mostly normal (the exceptions: slightly elevated TGF-Beta-1, low MSH, and low ADH, but other things can cause these results). Nonetheless, to further investigate the possibility, Dr. Bredesen recommended I do a urine mycotoxins test and later so did my local FM practitioner. In November 2017, I finally did that test and was found to have extraordinarily high levels of two mycotoxins.
So yes, I do have mold illness, which was also confirmed through a recent consultation with Dr. Mary Ackerley.
I feel conflicted about HLA-DR testing falling out of favor. If it weren't for my two mold-susceptible haplotypes, I likely would have dropped pursuing the possibility that I have mold illness.