PBW wrote: I had first appt with Mitsu in Jan(Palm Springs and my second appt is with Dr Gundry on Aug 12. I am busy making my list of questions to send to him prior to our appt. I will report what is going on after I meet with him.
TheresaB wrote:I've used photobiomodulation, previously known as Low Level Laser Therapy (LLLT), which applies red and near-infrared light for pain and inflammation purposes due to an orthopedic issue. It's warm, but not stressful, never thought I was activating heat shock proteins. I sauna regularly for the purpose of activating HSPs along with the its other benefits.
johnseed wrote:What temperature are your saunas Theresa? Do you have any evidence for the relationship of temperature to HSP's?
Heat stress, in particular, robustly activates HSPs.[18] For example, after healthy men and women sat in a heat stress chamber for 30 minutes at 73°C (163°F), their levels of HSP72 increased by 49 percent.[19] In a different study, in which healthy men and women were exposed to deep tissue heat therapy for six days, participants' levels of HSP70 and HSP90 increased 45 percent and 38 percent, respectively.[20] In addition, their biomarkers of mitochondrial biogenesis improved, and their mitochondrial function increased by 28 percent compared to baseline levels. The activation of HSPs is sustained over time, suggesting that heat acclimation induces whole-body adaptations that increase heat tolerance, resulting in protective cellular adaptations.[18]
johnseed wrote:What temperature are your saunas Theresa? Do you have any evidence for the relationship of temperature to HSP's?
TheresaB wrote:johnseed wrote:What temperature are your saunas Theresa? Do you have any evidence for the relationship of temperature to HSP's?
I don't mean to come off as flippant, but our sauna is home made and the temperature is whatever it is when I walk in. When fully warmed up, it does tend to range from in the 120s to 130s, but because our sauna is a converted bathtub sized walk-in shower stall, I sit very close to the heat lamps so it's quite hot (we use heat lamps that emit in the near infrared spectrum, spectrum is important too, not just heat).
Regarding temperature relationship to Heat Shock Proteins, let me refer you to this write-up on everything sauna by Dr Rhonda Patrick: https://www.foundmyfitness.com/topics/s ... k-proteins where she writes:Heat stress, in particular, robustly activates HSPs.[18] For example, after healthy men and women sat in a heat stress chamber for 30 minutes at 73°C (163°F), their levels of HSP72 increased by 49 percent.[19] In a different study, in which healthy men and women were exposed to deep tissue heat therapy for six days, participants' levels of HSP70 and HSP90 increased 45 percent and 38 percent, respectively.[20] In addition, their biomarkers of mitochondrial biogenesis improved, and their mitochondrial function increased by 28 percent compared to baseline levels. The activation of HSPs is sustained over time, suggesting that heat acclimation induces whole-body adaptations that increase heat tolerance, resulting in protective cellular adaptations.[18]
Dr Patrick probably got much of her information on saunas from Finnish cardiologist and researcher Dr. Jari Laukkanen. Her interview (and transcript) with him regarding his research and findings on Alzheimer's, cardiovascular implications, and longevity can be found at:
Dr. Jari Laukkanen on Sauna Use for the Prevention of Cardiovascular & Alzheimer’s Disease In Dr Laukkanen's research in Finland, the average temperature of the sauna was 79 celsius or 174 F.
johnseed wrote:The only relevant study I've found so far is Dr Laukkanen these saunas averaged 174. The 70% decrease in incidence of Alzheimer's (and 40% decrease in all cause mortality for men who used saunas 4 to 7 times a week is by far the most efficacious intervention I've read about, would you agree?
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